The following measures were recommended by the Working Group on Hypercholesterolemia
and Other Dyslipidemias in light of the new scientific evidence that became available since …

Background and Purpose— Ischemic stroke (IS) and coronary artery disease (CAD) share
several risk factors and each has a substantial heritability. We conducted a genome-wide …

Low-frequency coding DNA sequence variants in the proprotein convertase subtilisin/kexin
type 9 gene (PCSK9) lower plasma low-density lipoprotein cholesterol (LDL-C), protect …

Background High plasma HDL cholesterol is associated with reduced risk of myocardial
infarction, but whether this association is causal is unclear. Exploiting the fact that genotypes are …

The adipocyte-derived protein adiponectin is highly heritable and inversely associated with
risk of type 2 diabetes mellitus (T2D) and coronary heart disease (CHD). We meta-analyzed …

Analyzing 12,361 all-cause cirrhosis cases and 790,095 controls from eight cohorts, we
identify a common missense variant in the Mitochondrial Amidoxime Reducing Component 1 …

The 2021 guidelines primary panel selected clinically relevant questions and produced
updated recommendations, on the basis of important new findings that have emerged since the …

Common multi-allelic copy number variants (CNVs) appear enriched for phenotypic associations
compared to their biallelic counterparts 1 , 2 , 3 , 4 . Here we investigated the influence …

Background LDL cholesterol has a causal role in the development of cardiovascular disease.
Improved understanding of the biological mechanisms that underlie the metabolism and …

Objectives : The purpose of this study was to test the hypothesis that 9p21 gene dosage
determines the severity of coronary artery disease (CAD). Background : The 9p21 locus is the …