Structure-based design of prefusion-stabilized SARS-CoV-2 spikes
The coronavirus disease 2019 (COVID-19) pandemic has led to accelerated efforts to develop
therapeutics and vaccines. A key target of these efforts is the spike (S) protein, which is …
therapeutics and vaccines. A key target of these efforts is the spike (S) protein, which is …
An audit of the use of laser Doppler imaging (LDI) in the assessment of burns of intermediate depth
SA Pape, CA Skouras, PO Byrne - Burns, 2001 - Elsevier
This is the first report of an evaluation of the use of a laser Doppler imager (LDI) scanner in
the assessment of burn depth in patients. It is based on a 6-month, prospective audit of 76 …
the assessment of burn depth in patients. It is based on a 6-month, prospective audit of 76 …
[PDF][PDF] EGFR ligands differentially stabilize receptor dimers to specify signaling kinetics
Epidermal growth factor receptor (EGFR) regulates many crucial cellular programs, with seven
different activating ligands shaping cell signaling in distinct ways. Using crystallography …
different activating ligands shaping cell signaling in distinct ways. Using crystallography …
A laser Doppler scanner for imaging blood flow in skin
TJH Essex, PO Byrne - Journal of biomedical engineering, 1991 - Elsevier
This paper describes a novel medical instrument that produces an image of blood flow in the
capillaries under the skin surface. A laser beam is used to detect blood cell motion from the …
capillaries under the skin surface. A laser beam is used to detect blood cell motion from the …
How IGF-1 activates its receptor
10.7554/eLife.03772.001 The type I insulin-like growth factor receptor (IGF1R) is involved in
growth and survival of normal and neoplastic cells. A ligand-dependent conformational …
growth and survival of normal and neoplastic cells. A ligand-dependent conformational …
A single ligand is sufficient to activate EGFR dimers
Crystal structures of human epidermal growth factor receptor (EGFR) with bound ligand
revealed symmetric, doubly ligated receptor dimers thought to represent physiologically active …
revealed symmetric, doubly ligated receptor dimers thought to represent physiologically active …
Expression of Genes in Cyanobacteria: Adaptation of Endogenous Plasmids as Platforms for High-Level Gene Expression in Synechococcus sp. PCC 7002
Synechococcus sp. PCC 7002 is an ideal model cyanobacterium for functional genomics
and biotechnological applications through metabolic engineering. A gene expression system …
and biotechnological applications through metabolic engineering. A gene expression system …
Global strategy for asthma management and prevention: GINA executive summary
…, P Gibson, K Ohta, P O'Byrne… - European …, 2008 - Eur Respiratory Soc
Asthma is a serious health problem throughout the world. During the past two decades, many
scientific advances have improved our understanding of asthma and ability to manage and …
scientific advances have improved our understanding of asthma and ability to manage and …
Development and validation of a questionnaire to measure asthma control
EF Juniper, PM O'byrne, GH Guyatt… - European respiratory …, 1999 - Eur Respiratory Soc
International guidelines on asthma management indicate that the primary goal of treatment
should be optimum asthma control. The aim of this study was to develop and validate the …
should be optimum asthma control. The aim of this study was to develop and validate the …
[HTML][HTML] Effect of inhaled formoterol and budesonide on exacerbations of asthma
…, DS Postma, AE Tattersfield, P O'Byrne… - … England Journal of …, 1997 - Mass Medical Soc
Background The role of long-acting, inhaled β 2 -agonists in treating asthma is uncertain. In
a double-blind study, we evaluated the effects of adding inhaled formoterol to both lower and …
a double-blind study, we evaluated the effects of adding inhaled formoterol to both lower and …