Several epidemiological studies have reported that the regional distribution of body fat is a
significant and independent risk factor for cardiovascular disease (CVD) and related mortality. …

The amount of abdominal visceral adipose tissue measured by computed tomography is a
critical correlate of the potentially “atherogenic” metabolic disturbances associated with …

The effects of long-term negative energy balance generated by exercise while maintaining
a constant energy intake were studied in five healthy young males (25+/-3 years; mean+/-sd). …

Background Prospective studies suggest that hyperinsulinemia may be an important risk factor
for ischemic heart disease. However, it has not been determined whether plasma insulin …

We undertook this study to determine whether there are differences in the responses of
different persons to long-term overfeeding and to assess the possibility that genotypes are …

Background Case-control studies have reported that patients with ischemic heart disease (IHD)
have a higher proportion of small, dense LDL particles than do healthy control subjects. …

The relations of regional adipose tissue (AT) distribution measured by computed tomography
(CT) to plasma insulin-glucose homeostasis and lipoprotein-lipid levels were studied in 58 …

Background Results obtained largely from case-control studies have suggested that an
elevated plasma concentration of apolipoprotein (apo) B may be considered an important risk …

The outcome of the first pilot study of liver-directed gene therapy is reported here. Five patients
with homozygous familial hypercholesterolaemia (FH) ranging in age from 7 to 41 years …

An ex vivo approach to gene therapy for familial hypercholesterolaemia (FH) has been
developed in which the recipient is transplanted with autologous hepatocytes that are genetically …