[HTML][HTML] Sphincter of Oddi function and risk factors for dysfunction
The sphincter of Oddi (SO) is a smooth muscle valve regulating the flow of biliary and
pancreatic secretions into the duodenum, initially described in 1887 by the Italian anatomist, …
pancreatic secretions into the duodenum, initially described in 1887 by the Italian anatomist, …
[HTML][HTML] Eluxadoline for irritable bowel syndrome with diarrhea
…, R Lopez, L Turner, PS Covington - … England Journal of …, 2016 - Mass Medical Soc
Background Effective and safe treatments are needed for patients who have irritable bowel
syndrome (IBS) with diarrhea. We conducted two phase 3 trials to assess the efficacy and …
syndrome (IBS) with diarrhea. We conducted two phase 3 trials to assess the efficacy and …
[HTML][HTML] Eluxadoline benefits patients with irritable bowel syndrome with diarrhea in a phase 2 study
…, JM Davenport, G Mcintyre, JS Almenoff, PS Covington - Gastroenterology, 2013 - Elsevier
Background & Aims Simultaneous agonism of the μ-opioid receptor and antagonism of the δ-opioid
receptor can reduce abdominal pain and diarrhea in patients with irritable bowel …
receptor can reduce abdominal pain and diarrhea in patients with irritable bowel …
Evaluation of the Irritable Bowel Syndrome Quality of Life (IBS-QOL) questionnaire in diarrheal-predominant irritable bowel syndrome patients
…, DL Patrick, DA Drossman, PS Covington - Health and quality of life …, 2013 - Springer
… Paul S Covington … Dove L, Lembo A, Randall C, Fogel R, Andrae D, Davenport J, McIntyre
G, Almenoff J, Covington P: Eluxadoline benefits patients with irritable … Paul S Covington …
G, Almenoff J, Covington P: Eluxadoline benefits patients with irritable … Paul S Covington …
Safety of eluxadoline in patients with irritable bowel syndrome with diarrhea
…, PS Schoenfeld, LS Dove, PS Covington - Official journal of the …, 2017 - journals.lww.com
… Covington; Drafting and revision of the manuscript: Brooks D. Cash, Brian … Covington. All
authors approved the final draft of this … Covington serve as scientific consultants for Allergan plc. …
authors approved the final draft of this … Covington serve as scientific consultants for Allergan plc. …
Effects of chronic stress on sleep in rats
…, TN Robinson III, WL Wright, PS Covington - Physiology & …, 1995 - Elsevier
The present study was conducted to determine the effects of chronic stress on sleep using a
rodent paradigm of around-the-clock signalled intermittent foot shock in which some rats can …
rodent paradigm of around-the-clock signalled intermittent foot shock in which some rats can …
Eluxadoline efficacy in IBS-D patients who report prior loperamide use
…, AJ Lembo, LS Dove, PS Covington - Official journal of the …, 2017 - journals.lww.com
… Covington; drafting and revision of the manuscript: Brian E. Lacy, William … Covington. All
authors approved the final draft of this … Covington serve as scientific consultants for Allergan plc. …
authors approved the final draft of this … Covington serve as scientific consultants for Allergan plc. …
Abuse potential and pharmacodynamic characteristics of oral and intranasal eluxadoline, a mixed μ-and κ-opioid receptor agonist and δ-opioid receptor antagonist
…, M McDonnell, JM Davenport, PS Covington… - … of Pharmacology and …, 2016 - ASPET
Drugs with μ-opioid receptor (OR) activity can be associated with abuse and misuse. The
peripherally acting mixed μ-OR and κ-OR agonist and δ-OR antagonist eluxadoline is …
peripherally acting mixed μ-OR and κ-OR agonist and δ-OR antagonist eluxadoline is …
Early response predicts a sustained response to eluxadoline in patients with irritable bowel syndrome with diarrhoea in two Phase 3 studies
…, LS Dove, DA Andrae, PS Covington - Alimentary …, 2017 - Wiley Online Library
Background The mixed μ‐ and κ‐opioid receptor agonist and δ‐opioid receptor antagonist,
eluxadoline, is licensed in the USA for the treatment of irritable bowel syndrome with …
eluxadoline, is licensed in the USA for the treatment of irritable bowel syndrome with …
Impact of patient and disease characteristics on the efficacy and safety of eluxadoline for IBS-D: a subgroup analysis of phase III trials
…, C Gutman, LS Dove, PS Covington… - Therapeutic …, 2019 - journals.sagepub.com
… Covington has served as a consultant for Allergan plc. Anthony Lembo serves as a
consultant for Allergan plc, Ironwood Pharmaceuticals, Napo Pharmaceuticals, Prometheus …
consultant for Allergan plc, Ironwood Pharmaceuticals, Napo Pharmaceuticals, Prometheus …
