Aims To critically evaluate the clinical implications of the use of non-fasting rather than
fasting lipid profiles and to provide guidance for the laboratory reporting of abnormal non-fasting …

High levels of lipoprotein(a) [Lp(a)], an apoB100-containing lipoprotein, are an independent
and causal risk factor for atherosclerotic cardiovascular diseases through mechanisms …

… In case-control studies, Kamstrup et al. found that a doubling of genetically determined
lipoprotein(a) was associated with a 12%–16% increased risk of atherosclerotic stenotic disease …

… Author Contributions: Dr Kamstrup had full access to all of the data in the study and takes …
Dr Kamstrup reported being a consultant for Abbott. Dr Steffensen reported no financial …

Background Limited information is available regarding genetic contributions to valvular
calcification, which is an important precursor of clinical valve disease. Methods We determined …

Background— Elevated lipoprotein(a) levels are associated with myocardial infarction (MI)
in some but not all studies. Limitations of previous studies include lack of risk estimates for …

Objectives : The purpose of this study was to determine whether elevated lipoprotein(a) levels
and corresponding LPA risk genotypes (rs10455872, rs3798220, kringle IV type 2 repeat …

We screened variants on an exome-focused genotyping array in> 300,000 participants (replication
in> 280,000 participants) and identified 444 independent variants in 250 loci …

Importance Human genetic studies have indicated that plasma lipoprotein(a) (Lp[a]) is causally
associated with the risk of coronary heart disease (CHD), but randomized trials of several …

Coronary artery disease (CAD) is a leading cause of morbidity and mortality worldwide 1 , 2
. Although 58 genomic regions have been associated with CAD thus far 3 , 4 , 5 , 6 , 7 , 8 , 9 , …