Type I interferons (IFNs) play an essential role in the host response to viral infection through
the induction of numerous IFN-stimulated genes (ISGs), including important antiviral …

Ubiquitin (Ub) and interferon-stimulated gene product 15 (ISG15) reversibly conjugate to
proteins and mediate important innate antiviral responses. The ovarian tumor (OTU) domain …

The innate immune response, and in particular the alpha/beta interferon (IFN-α/β) system,
plays a critical role in the control of viral infections. Interferons α and β exert their antiviral …

Though the interferon-inducible protein ISG15 was one of the first ubiquitin-like modifiers to
be discovered, much remains unknown about the identity of proteins conjugated to ISG15 or …

Protein ISGylation is unique among ubiquitin-like conjugation systems in that the
expression and conjugation processes are induced by specific stimuli, mainly via the alpha/beta …

Objective The use of robotic radical hysterectomy has greatly increased in the treatment of
early stage cervical cancer. We sought to compare surgical and oncologic outcomes of …

Interferon (IFN)-stimulated gene 15 (ISG15) is a ubiquitin-like molecule that conjugates to
target proteins via a C-terminal LRLRGG motif and has antiviral function in vivo. We used …

These findings provide new mechanistic insight into progression of ductal carcinoma and
support clinical application of MNK1 inhibitors to delay progression of indolent ductal …

Objective To determine the underlying histopathologic features influencing apparent
diffusion coefficient (ADC) values of breast fibroadenomas. Materials and Methods Biopsy-proven …

DNA aneuploidy characterizes a proportion of malignant bone marrow(BM)-localized plasma
cells in multiple myeloma (MM). This analysis shows that for most MM patients, circulating …