Importance The evidence for benefit of convalescent plasma for critically ill patients with
COVID-19 is inconclusive. Objective To determine whether convalescent plasma would improve …

Background: Frailty is a multidimensional syndrome characterized by loss of physiologic
and cognitive reserves that confers vulnerability to adverse outcomes. We determined the …

Importance Growing interest in microbial dysbiosis during critical illness has raised
questions about the therapeutic potential of microbiome modification with probiotics. Prior …

The International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC) is
a global federation of clinical research networks that work collaboratively to prevent illness …

OBJECTIVES: Studies have suggested intrapulmonary shunts may contribute to hypoxemia
in COVID-19 acute respiratory distress syndrome (ARDS) with worse associated outcomes. …

Background Sedation of critically ill patients with inhaled anaesthetics may reduce lung
inflammation, time to extubation, and ICU length of stay compared with intravenous (iv) sedatives…

Potato (Solanum tuberosum L.) is one of the most important crops with a worldwide
production of 370 million metric tons. The objectives of this study were (1) to create a high-quality …

Importance Research diversity and representativeness are paramount in building trust,
generating valid biomedical knowledge, and possibly in implementing clinical guidelines. …

Predictive breeding approaches, like phenomic or genomic selection, have the potential to
increase the selection gain for potato breeding programs which are characterized by very …

Background Intravenous (IV) vasopressors to support hemodynamics are a primary indication
for intensive care unit (ICU) admission. Utilization of oral vasopressor therapy may offer an …