Article abstract The causes and geographic distribution of 267 cases of iatrogenic
Creutzfeldt–Jakob disease (CJD) are here updated at the millennium. Small numbers of still-occurring …

… Reprinted from Trojan DA, Gendron D, Cashman NR. Anticholinesterase-responsive
neuromuscular junction transmission defects in post-poliomyelitis fatigue. J Neurol Sci 114:170–177…

Amyotrophic lateral sclerosis (ALS) is primarily characterized by progressive loss of motor
neurons, although there is marked phenotypic heterogeneity between cases. Typical, or “…

… of motor neurons from other neuronal populations is poorly understood (Cashman, 1992).
Low yields and limited purity of mo… Cashman for their assistance in preparing the manuscript. …

In late 1987 there was an outbreak in Canada of gastrointestinal and neurologic symptoms
after the consumption of mussels found to be contaminated with domoic acid, which is …

The TAR DNA-binding protein 43 (TDP-43) has been identified as the major disease protein
in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with ubiquitin …

The “modified host protein” model of scrapie proposes that the transmissible agent is
composed of the degradation-resistant protein, Sp33–37, and that clinical and pathologic signs …

Amyotrophic lateral sclerosis (ALS) is predominantly sporadic, but associated with heritable
genetic mutations in 5–10% of cases, including those in Cu/Zn superoxide dismutase (SOD1…

Proteinacious intracellular aggregates in motor neurons are a key feature of both sporadic
and familial amyotrophic lateral sclerosis (ALS). These inclusion bodies are often …

The scrapie agent protein (Sp33-37 or PrPSC) is the disease-associated isoform of a normal
cellular membrane protein (Cp33-37 or PrPc) of unknown function. We report that normal …