Background Irritable bowel syndrome (IBS) is a common chronic gastrointestinal disorder.
The role of pharmacotherapy for IBS is limited and focused mainly on symptom control. …

Background : Both high‐fibre dietary advice and the prescription of fibre as a bulking agent
are very common in primary and secondary care management of irritable bowel syndrome. …

… Previously mentioned authors, Helsper, CW and de Wit, NJ contributed to the concept and
design of the study. Luigjes-Huizer, YL and Tauber, NM conducted the systematic review and …

Background: A response to proton-pump inhibitors (PPIs) is commonly considered to support
the diagnosis of gastroesophageal reflux disease (GERD). However, the accuracy of this …

Functional dyspepsia is a common disorder witha diverse pathophysiological background,
but the role ofmotility disorders in functional dyspepsia remainsunclear. We aimed to quantify …

RESEARCH Page 1 RESEARCH Soluble or insoluble fibre in irritable bowel syndrome in
primary care? Randomised placebo controlled trial CJ Bijkerk, general practitioner,1 NJ de Wit…

… Niek J de Wit , Niek J de Wit … Opstelten W, Mauritz JW, de Wit NJ, van Wijck AJM, Stalman
WAB and van Essen GA. Herpes zoster and postherpetic neuralgia: incidence and risk …

Dietary saturated fat is linked to numerous chronic diseases, including cardiovascular
disease. Here we study the role of the lipoprotein lipase inhibitor Angptl4 in the response to …

Background No consensus exists on the optimal treatment for irritable bowel syndrome
(IBS). Psychological treatments are increasingly advocated but their effectiveness is unclear …

Background Obesity and insulin resistance are two major risk factors underlying the metabolic
syndrome. The development of these metabolic disorders is frequently studied, but mainly …