OBJECTIVE: To review the results of randomized controlled trials on the effectiveness of
brief physician interventions with problem drinkers. DATA SOURCES: The MEDLINE and …

Objective: To improve awareness and knowledge of problematic substance use in pregnancy
and to provide evidence-based recommendations for the management of this challenging …

Objective To provide family physicians with a practical clinical summary of the Canadian
Guideline for Safe and Effective Use of Opioids for Chronic Non-Cancer Pain, developed by the …

Background: Benzodiazepine use by elderly patients is associated with adverse outcomes
including increased risk of falls and fractures, motor vehicle accidents and cognitive …

Objective To advise physicians on which treatment options to recommend for specific
patient populations: abstinence-based treatment, buprenorphine-naloxone maintenance, or …

Objective To provide family physicians with a practical clinical summary of opioid prescribing
for specific populations based on recommendations from the Canadian Guideline for Safe …

OBJECTIVE To review the evidence on identifying and managing misuse of and dependence
on opioids among primary care patients with chronic pain. QUALITY OF EVIDENCE …

We aimed to examine pharmacologic, demographic and medical comorbidity risk factors for
opioid-related mortality among patients currently receiving methadone for an opioid use …

There is a high prevalence of alcohol use, abuse, and dependence in methadone maintenance
treatment (MMT) programs. There have been reports that this may be a result of entry …

Objective To offer preliminary guidance on prescribing smoked cannabis for chronic pain
before the release of formal guidelines. Quality of evidence We reviewed the literature on the …