Background There is substantial variability in the perioperative administration of aspirin in
patients undergoing noncardiac surgery, both among patients who are already on an aspirin …

Objective To synthesise the association of shift work with major vascular events as reported
in the literature. Data sources Systematic searches of major bibliographic databases, contact …

Objectives A P-value <0.05 is one metric used to evaluate the results of a randomized controlled
trial (RCT). We wondered how often statistically significant results in RCTs may be lost …

Importance Obstructive sleep apnea is a common disease, responsible for daytime sleepiness.
Prior to referring patients for definitive testing, the likelihood of obstructive sleep apnea …

Background Marked activation of the sympathetic nervous system occurs during and after
noncardiac surgery. Low-dose clonidine, which blunts central sympathetic outflow, may …

Background Myocardial injury after non-cardiac surgery (MINS) increases the risk of
cardiovascular events and deaths, which anticoagulation therapy could prevent. Dabigatran …

Objective: We synthesized the epidemiologic evidence concerning selective serotonin
reuptake inhibitor (SSRI) exposure and the risk of CNS hemorrhage. Methods: We searched for …

Background— A recent large, randomized trial suggested that statins may increase the risk
of intracerebral hemorrhage. Accordingly, we systematically reviewed the association of …

Background In non-surgical settings, covert stroke is more common than overt stroke and is
associated with cognitive decline. Although overt stroke occurs in less than 1% of adults after …

Objective To identify existing prognostic delirium prediction models and evaluate their
validity and statistical methodology in the older adult (≥60 years) acute hospital population. …