Background Concurrent treatment with temozolomide and radiotherapy followed by maintenance
temozolomide is the standard of care for patients with newly diagnosed glioblastoma. …

The evolutionary processes that drive universal therapeutic resistance in adult patients with
diffuse glioma remain unclear 1 , 2 . Here we analysed temporally separated DNA-…

The introduction and expression of genes in somatic cells is an innovative therapy for correcting
genetic deficiency diseases and augmenting immune function. A potential obstacle to …

The purpose of this study was to compare the excitability and contractility of three-dimensional
skeletal muscle constructs, termed myooids, engineered from C 2 C 12 myoblast and …

Background Seizures can present at any time before or after diagnosis of a brain tumor. The
risk of seizures varies by tumor type and its location in the brain. For a long time we believed …

Currently, the most widely used criteria for assessing response to therapy in high-grade
gliomas are based on two-dimensional tumor measurements on computed tomography (CT) or …

Background Cytomegalovirus (CMV) disease in immunocompromised patients correlates
with a deficiency of CD8+ cytotoxic T lymphocytes specific for CMV. We evaluated the safety …

Purpose Radiotherapy with concomitant and adjuvant temozolomide is the standard of care
for newly diagnosed glioblastoma (GBM). O 6-methylguanine-DNA methyltransferase (…

Glioblastomas are the most common form of malignant primary brain tumor and an important
cause of morbidity and mortality. In recent years there have been important advances in …

Resistance to alkylating agents via direct DNA repair by O(6)-methylguanine methyltransferase
(MGMT) remains a significant barrier to the successful treatment of patients with …