Context.—Current guidelines recommend that individuals infected with the human
immunodeficiency virus type 1 (HIV-1) be treated using combinations of antiretroviral agents to …

Background Nucleoside analogues can induce toxic effects on mitochondria by inhibiting the
human DNA polymerase γ. The toxic effects can range from increased serum lactate levels …

LONG-TERM REMISSION OF HIV-1 DISEASE CAN BE READILY ACHIEVED by combinations
of antiretroviral agents. The suppression of plasma viral loads to less than the limit of …

We herein present an overview of the upcoming 5 th edition of the World Health Organization
Classification of Haematolymphoid Tumours focussing on lymphoid neoplasms. Myeloid …

Many tumour cells have elevated rates of glucose uptake but reduced rates of oxidative
phosphorylation. This persistence of high lactate production by tumours in the presence of …

In animals, cells are dependent on extracellular signals to prevent apoptosis. However, using
growth factor-dependent cells from Bax/Bak-deficient mice, we demonstrate that apoptosis …

Cancer cells frequently display high rates of aerobic glycolysis in comparison to their
nontransformed counterparts, although the molecular basis of this phenomenon remains poorly …

Lymphocyte activation initiates a program of cell growth, proliferation, and differentiation
that increases metabolic demand. Although T cells increase glucose uptake and glycolysis …

MicroRNAs are abundant in animal genomes and have been predicted to have important roles
in a broad range of gene expression programmes 1 , 2 . Despite this prominence, there is …

Objective To provide population-based estimates of the prevalence of lipodystrophy syndrome
and constituent symptoms and to identify correlates of prevalent symptomology. Methods …