We investigated several phenotypic and functional parameters of T cell-mediated immunity
in a large series of common variable immunodeficiency (CVID) patients. We demonstrated …

Differential gene expression of cell lines derived from a malignant melanoma or its autologous
lymph node metastasis using cDNA arrays indicated down-regulation of PRSS11, a gene …

The AS-30D rat hepatoma cell line is characteristic of that class of rapidly growing tumors
which exhibit high rates of aerobic glucose utilization and lactic acid production (Bustamante, E…

Two genes, p107 and Rb2/p130, are strictly related to RB, the most investigated tumor
suppressor gene, responsible for susceptibility to retinoblastoma. The products of these three …

The human HtrA family of proteases consists of three members: HtrA1, HtrA2, and HtrA3. In
bacteria, the chief role of HtrA is recognition and degradation of misfolded proteins in the …

Background Cathepsins represent a group of proteases involved in determining the metastatic
potential of cancer cells. Among these are cysteinyl- (eg cathepsin B and cathepsin L) …

Background: Many academic medical centres have introduced strategies to assess the
productivity of faculty as part of compensation schemes. We conducted a systematic review of the …

Despite the clonal origin of most tumors, their tremendous heterogeneity suggests that
cancer progression springs from the combined forces of both genetic and epigenetic events, …

Serum and glucocorticoid regulated kinase 1 (Sgk1) is a serine–threonine kinase that is
activated by serum, steroids, insulin, vasopressin, and interleukin 2 at the transcriptional and …

Background The very limited time allowed to face the COVID-19 pandemic poses a pressing
challenge to find proper therapeutic approaches. However, synthesis and full investigation …