Electrospray ionization has recently emerged as a powerful technique for producing intact
ions in vacuo from large and complex species in solution. To an extent greater than has …

… & Mann, M. MaxQuant enables high peptide identification rates, individualized ppb-range
mass … & Mann, M. Protein interaction screening by quantitative immunoprecipitation combined …

… analyser that measures the mass-to-charge ratio (m/z) of the ionized analytes, and a detector
that registers the number of ions at each m/z value. Electrospray ionization (ESI) and matrix-…

The recent abundance of genome sequence data has brought an urgent need for systematic
proteomics to decipher the encoded protein networks that dictate cellular function 1 . To …

To identify CAP3 and CAP4, components of the CD95 (Fas/APO-1) death-inducing signaling
complex, we utilized nano-electrospray tandem mass spectrometry, a recently developed …

Spatially resolved global reconstructions of annual surface temperature patterns over the
past six centuries are based on the multivariate calibration of widely distributed high-resolution …

Lysine acetylation is a reversible posttranslational modification of proteins and plays a key
role in regulating gene expression. Technological limitations have so far prevented a global …

… In the peptide map of band 5, we observed an intensive doubly charged peak at m/z 685.9
(Figure 5A). A series of ions assumed to be Y‘‘ ions, which specified the partial sequence EVS…

Protein quantification without isotopic labels has been a long-standing interest in the
proteomics field. However, accurate and robust proteome-wide quantification with label-free …

… The nanoLC MS/MS experiments were repeated with precursor ions selected from restricted
m/z ranges (m/z 350–550, 545–750 and 745–1,400) matched by pulsed extraction of the …