Many studies have investigated the effectiveness of interventions in promoting advance
directives (ADs) but there is uncertainty as to what works best, and in whom. We conducted a …

Previous studies about the association of multimorbidity and the health-related quality of life
(HRQOL) in primary-care patients are limited because of their reliance on simple counts of …

Background and Purpose—Very few population-based studies have systematically examined
incident vascular dementia (VaD). From the Canadian Study of Health and Aging cohort, …

Background and Purpose— Using confirmatory factor analysis, this study evaluates the
relative impact of motor, cognitive, and perceptual deficits on functional autonomy with 100 …

PURPOSE Psychological distress may decrease adherence to medical treatments and lead
to poorer health outcomes of chronic diseases. The aim of this study was to evaluate the …

… MF participated in the conception and design of the study, supervised data collection and
analysis and drafted the manuscript. M-FD participated in the conception and design of the …

Background. In Canada, half the people with dementia live in institutions. Factors associated
with institutionalization should be identified with the goal of implementing strategies not …

Many comprehensive rating scales have been developed to assess disabilities. These
assessments, which require significant amounts of time, are usually performed by trained …

Vascular dementia (VaD) is the second commonest subtype of dementia after Alzheimer’s
disease (AD). However, its incidence has been studied much less extensively than that of AD. …

α-Amanitin is a well-known specific inhibitor of RNA polymerase II (RNAPII) in vitro and in
vivo. It is a cyclic octapeptide which binds with high affinity to the largest subunit of RNAPII, …