[HTML][HTML] Colchicine for community-treated patients with COVID-19 (COLCORONA): a phase 3, randomised, double-blinded, adaptive, placebo-controlled, multicentre …
…, M Cossette, A Nozza, M Chabot-Blanchet… - The Lancet …, 2021 - thelancet.com
Background Evidence suggests a role for excessive inflammation in COVID-19 complications.
Colchicine is an oral anti-inflammatory medication beneficial in gout, pericarditis, and …
Colchicine is an oral anti-inflammatory medication beneficial in gout, pericarditis, and …
Efficacy of colchicine in non-hospitalized patients with COVID-19
…, M Cossette, A Nozza, M Chabot-Blanchet… - Medrxiv, 2021 - medrxiv.org
Background Evidence suggests the role of an inflammatory storm in COVID-19 complications.
Colchicine is an orally administered, anti-inflammatory medication beneficial in gout, …
Colchicine is an orally administered, anti-inflammatory medication beneficial in gout, …
[HTML][HTML] TNF-α antagonist and vascular inflammation in patients with psoriasis vulgaris: a randomized placebo-controlled study
…, JG Krueger, MC Guertin, M Chabot-Blanchet… - Journal of Investigative …, 2017 - Elsevier
Vascular inflammation is increased in patients with psoriasis. This randomized, double-blind,
multicenter study evaluated the effects of tumor necrosis factor-α antagonist adalimumab …
multicenter study evaluated the effects of tumor necrosis factor-α antagonist adalimumab …
Lipid lowering in healthy volunteers treated with multiple doses of MGL-3196, a liver-targeted thyroid hormone receptor-β agonist
R Taub, E Chiang, M Chabot-Blanchet, MJ Kelly… - Atherosclerosis, 2013 - Elsevier
MGL-3196 is an oral, liver-targeted selective agonist for the thyroid hormone receptor-β (THR-β)
that is being developed for the treatment of dyslipidemia. The safety profile and …
that is being developed for the treatment of dyslipidemia. The safety profile and …
The benefits conferred by radial access for cardiac catheterization are offset by a paradoxical increase in the rate of vascular access site complications with femoral …
L Azzalini, K Tosin, M Chabot-Blanchet, R Avram… - JACC: Cardiovascular …, 2015 - jacc.org
Objectives : The purpose of this study was to assess whether the benefits conferred by
radial access (RA) at an individual level are offset by a proportionally greater incidence of …
radial access (RA) at an individual level are offset by a proportionally greater incidence of …
[HTML][HTML] Brain-derived neurotrophic factor mitigates the association between platelet dysfunction and cognitive impairment
…, L Starnino, M Welman, M Chabot-Blanchet… - Frontiers in …, 2021 - frontiersin.org
Background: Platelet hyperactivity is deleterious in coronary artery disease (CAD), requiring
lifelong antiplatelet therapy, and is associated with worse cognitive outcomes. Upon …
lifelong antiplatelet therapy, and is associated with worse cognitive outcomes. Upon …
A disease-specific comorbidity index for predicting mortality in patients admitted to hospital with a cardiac condition
L Azzalini, M Chabot-Blanchet, DA Southern, A Nozza… - Cmaj, 2019 - Can Med Assoc
BACKGROUND: Comorbidity indexes derived from administrative databases are essential
tools of research in global health. We sought to develop and validate a novel cardiac-specific …
tools of research in global health. We sought to develop and validate a novel cardiac-specific …
[HTML][HTML] Genetics of symptom remission in outpatients with COVID-19
…, LM Chicoine, M Cossette, M Chabot-Blanchet… - Scientific Reports, 2021 - nature.com
We conducted a genome-wide association study of time to remission of COVID-19 symptoms
in 1723 outpatients with at least one risk factor for disease severity from the COLCORONA …
in 1723 outpatients with at least one risk factor for disease severity from the COLCORONA …
[HTML][HTML] Beneficial Effects of Reconstituted High-Density Lipoprotein (rHDL) on Circulating CD34+ Cells in Patients after an Acute Coronary Syndrome
…, MA Alam, CYW Lee, L Boileau, M Chabot-Blanchet… - Plos one, 2017 - journals.plos.org
Background High-density lipoproteins (HDL) favorably affect endothelial progenitor cells (EPC).
Circulating progenitor cell level and function are impaired in patients with acute …
Circulating progenitor cell level and function are impaired in patients with acute …
Apolipoprotein AI proteolysis in aortic valve stenosis: role of cathepsin S
…, T Mihalache-Avram, Y Shi, M Chabot-Blanchet… - Basic Research in …, 2018 - Springer
Aortic valve stenosis (AVS) is the most common valvular heart disease in the Western world.
Therapy based on apolipoprotein AI (apoA-I), the major protein component of high-density …
Therapy based on apolipoprotein AI (apoA-I), the major protein component of high-density …