User profiles for M. R. Sears

Malcolm Sears

Professor of Medicine, McMaster University
Verified email at mcmaster.ca
Cited by 51827

[HTML][HTML] Asthma: epidemiology, etiology and risk factors

P Subbarao, PJ Mandhane, MR Sears - Cmaj, 2009 - Can Med Assoc
Methods This paper arose from an extensive literature review undertaken in developing the
Canadian Healthy Infant Longitudinal Development (CHILD) study, a multicentre national …

The respiratory effects of cannabis dependence in young adults

…, R Poulton, TE Moffitt, P Ramankutty, MR Sears - …, 2000 - Wiley Online Library
Aim. To evaluate the relationship between cannabis dependence and respiratory symptoms
and lung function in young adults, while controlling for the effects of tobacco smoking. …

Adverse effects of β-agonists

MR Sears - Journal of Allergy and Clinical Immunology, 2002 - Elsevier
… Dr Sears: I believe that what happened was that when fenoterol was launched, we used
it particularly in patients with troublesome asthma, quite unaware that we were unknowingly …

A gradient of childhood self-control predicts health, wealth, and public safety

…, BW Roberts, S Ross, MR Sears… - Proceedings of the …, 2011 - National Acad Sciences
Policy-makers are considering large-scale programs aimed at self-control to improve citizens’
health and wealth and reduce crime. Experimental and economic studies suggest such …

An official American Thoracic Society/European Respiratory Society statement: asthma control and exacerbations: standardizing endpoints for clinical asthma trials …

…, MR Partridge, ID Pavord, MR Sears… - American journal of …, 2009 - atsjournals.org
Background: The assessment of asthma control is pivotal to the evaluation of treatment
response in individuals and in clinical trials. Previously, asthma control, severity, and …

[HTML][HTML] A longitudinal, population-based, cohort study of childhood asthma followed to adulthood

MR Sears, JM Greene, AR Willan… - … England Journal of …, 2003 - Mass Medical Soc
Background The outcome of childhood asthma in adults has been described in high-risk
cohorts, but few population-based studies have reported the risk factors for persistence and …

Early infancy microbial and metabolic alterations affect risk of childhood asthma

…, A Becker, KM McNagny, MR Sears… - Science translational …, 2015 - science.org
Asthma is the most prevalent pediatric chronic disease and affects more than 300 million
people worldwide. Recent evidence in mice has identified a “critical window” early in life where …

Association between children's experience of socioeconomic disadvantage and adult health: a life-course study

…, A Caspi, BJ Milne, WM Thomson, A Taylor, MR Sears… - The lancet, 2002 - thelancet.com
Background Research into social inequalities in health has tended to focus on low
socioeconomic status in adulthood. We aimed to test the hypothesis that children's experience of …

Regular inhaled beta-agonist treatment in bronchial asthma

MR Sears, DR Taylor, CG Print, DC Lake, Q Li… - The Lancet, 1990 - Elsevier
89 subjects with stable asthma took part in a double-blind, placebo-controlled, randomised,
crossover study of the effects of regular versus on-demand inhaled bronchodilator therapy. …

[HTML][HTML] Relation between airway responsiveness and serum IgE in children with asthma and in apparently normal children

MR Sears, B Burrows, EM Flannery… - … England Journal of …, 1991 - Mass Medical Soc
Background. Although asthma diagnosed by a physician is known to be related to serum
IgE levels, it is not known whether there is a relation between the level of IgE and airway …