Although RNA and RNA-binding proteins have been linked to double-strand breaks (DSBs),
little is known regarding their roles in the cellular response to DSBs and, if any, in the repair …

BACKGROUND: The Personal Genome Project Canada is a comprehensive public data
resource that integrates whole genome sequencing data and health information. We describe …

… However, it is accepted that multiple clones per patient should be used for iPSC-based
disease modeling to account for the variability between clones from one donor (Hildebrandt et al., …

Induced pluripotent stem cells (iPSC) derived from healthy individuals are important
controls for disease-modeling studies. Here we apply precision health to create a high-quality …

Rett syndrome (RTT) is a severe neurodevelopmental disorder primarily caused by heterozygous
loss-of-function mutations in the X-linked gene MECP2 that is a global transcriptional …

DEAD box 1 (DDX1) is a member of the DEAD box family of RNA helicases which are involved
in all aspects of RNA metabolism. DDX1 has been implicated in a variety of biological …

Temporally-regulated maternal RNA translation is essential for embryonic development, with
defective degradation resulting in stalled 2-cell embryos. We show that DDX1, a DEAD box …

Human Rap1-interacting factor 1 (RIF1) is an important player in the repair of DNA double
strand breaks (DSBs). RIF1 acts downstream of 53BP1, with well-documented roles in class …

Mammalian DDX1 has been implicated in RNA trafficking, DNA double-strand break repair
and RNA processing; however, little is known about its role during animal development. Here…

Objectives : The aim of this study was to determine the feasibility of computed tomography (CT)-based
dynamic myocardial perfusion imaging for the assessment of myocardial ischemia …