Identification and management of frailty in the primary care setting

…, D Rolfson, AS Khera, J Dabravolskaj, E Dent, L Xia - Cmaj, 2018 - Can Med Assoc
This review was informed by clinical experience, best practice guidelines and literature
review. We searched PubMed using combinations of the following terms:“frail elderly,”“frailty,”“…

Improving Care Experiences, Efficiencies and Quality of Care for Seniors in Alberta.

…, S Khera, J Dabravolskaj, L Xia - … Quarterly (Toronto, Ont.), 2017 - europepmc.org
1. Care of the elderly physician and site lead, geriatric program, at the Misericordia Hospital;
Dr. Abbasi provides care for seniors in a variety of settings (inpatient, outpatient, …

The MC4 receptor agonist RO27‐3225 inhibits NLRP1‐dependent neuronal pyroptosis via the ASK1/JNK/p38 MAPK pathway in a mouse model of intracerebral …

…, D Doycheva, F Liu, JH Zhang, Y Xia… - British Journal of …, 2019 - Wiley Online Library
… Adult male CD1 mice (8-week-old, weight 30–40 g; Charles River, IMSR Cat# CRL:22,
RRID:IMSR_CRL:22) were housed in the designated animal care facility at Loma Linda

Crystal Structure of the Cytochrome bc1 Complex from Bovine Heart Mitochondria

D Xia, CA Yu, H Kim, JZ Xia, AM Kachurin, L Zhang… - Science, 1997 - science.org
On the basis of x-ray diffraction data to a resolution of 2.9 angstroms, atomic models of most
protein components of the bovine cytochrome bc 1 complex were built, including core 1, …

The anti-tumor efficacy and immune effects of combining of ceralasertib, an oral ATR kinase inhibitor, with imipridones, in prostate cancer treatment in vitro and in vivo

YL Xia, L Zhang, M Ghandali, MP Schwermann… - Cancer Research, 2024 - AACR
Prostate cancer is the most common cancer and the second leading cause of cancer death
among men in the United States. There is an estimated 10% to 50% of cases progress to …

The cancer metabolic reprogramming and immune response

L Xia, L Oyang, J Lin, S Tan, Y Han, N Wu, P Yi, L Tang… - Molecular cancer, 2021 - Springer
The overlapping metabolic reprogramming of cancer and immune cells is a putative determinant
of the antitumor immune response in cancer. Increased evidence suggests that cancer …

The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-β production

…, M Balastik, G Finn, G Wulf, J Lim, SH Li, X Li, W Xia… - Nature, 2006 - nature.com
Neuropathological hallmarks of Alzheimer's disease are neurofibrillary tangles composed of
tau and neuritic plaques comprising amyloid-β peptides (Aβ) derived from amyloid …

Serum ceramides increase the risk of Alzheimer disease: the Women's Health and Aging Study II

MM Mielke, VVR Bandaru, NJ Haughey, J Xia… - Neurology, 2012 - AAN Enterprises
Objectives: Previous studies have shown that high serum ceramides are associated with
memory impairment and hippocampal volume loss, but have not examined dementia as an …

The POU2F1-ALDOA axis promotes the proliferation and chemoresistance of colon cancer cells by enhancing glycolysis and the pentose phosphate pathway activity

J Lin, L Xia, L Oyang, J Liang, S Tan, N Wu, P Yi, Q Pan… - Oncogene, 2022 - nature.com
Cancer metabolic reprogramming enhances its malignant behaviors and drug resistance,
which is regulated by POU domain transcription factors. This study explored the effect of POU …

[HTML][HTML] Do as i can, not as i say: Grounding language in robotic affordances

…, AT Toshev, V Vanhoucke, F Xia… - … on robot learning, 2023 - proceedings.mlr.press
Large language models can encode a wealth of semantic knowledge about the world. Such
knowledge could be extremely useful to robots aiming to act upon high-level, temporally …