Leukocyte infiltration in the CNS after trauma or inflammation is triggered in part by upregulation
of the chemokine, monocyte chemoattractant protein-1 (MCP-1), in astrocytes. However …

An acute trauma to the CNS rapidly results in the upregulation of inflammatory cytokines
that include interleukin‐1 (IL‐1). We report here that the levels of several matrix …

Injury to the CNS results in the production and accumulation of inflammatory cytokines within
this tissue. The origin and role of inflammation within the CNS remains controversial. In this …

The CNS response to injury is characterized by the rapid activation of astrocytes in a process
known as astrogliosis. The function of reactive astrocytes is controversial, in that both …

The objective of this study was to generate an immortal cell line representative of specialized
human brain microvascular endothelia forming the blood–brain barrier (BBB) in vivo. …

Palliative care is an evolving field with extensive studies demonstrating its benefits to
patients, families, and the health care system. Many health systems have developed or are …

Background: Routine early palliative care (EPC) improves quality of life (QoL) for patients
with advanced cancer, but it may not be necessary for all patients. We assessed the feasibility …

Several studies have reported beneficial effects of intravenous immunoglobulin (IVIg) in
diseases of the neuroaxis. However, IVIg effects on leucocyte recruitment, a hallmark feature of …

Implantable cardioverter defibrillators (ICDs) prevent sudden cardiac death. However, in
patients with terminal illnesses, these devices may disrupt the dying process. This study was …

Pain is highly prevalent in patients with cancer—nearly 40% report moderate-severe pain,
which is commonly treated with opioids. Increasing cancer survivorship, opioid epidemics in …