Background: This document provides evidence-based clinical practice guidelines on the use
of mechanical ventilation in adult patients with acute respiratory distress syndrome (ARDS). …

In ARDS patients, the change from supine to prone position generates a more even
distribution of the gas–tissue ratios along the dependent–nondependent axis and a more …

Rationale: The application of prone positioning for acute respiratory distress syndrome (ARDS)
has evolved, with recent trials focusing on patients with more severe ARDS, and applying …

The aim of these guidelines is to update the 2017 clinical practice guideline (CPG) of the
European Society of Intensive Care Medicine (ESICM). The scope of this CPG is limited to adult …

Importance Treatment with noninvasive oxygenation strategies such as noninvasive ventilation
and high-flow nasal oxygen may be more effective than standard oxygen therapy alone …

Background Use of extracorporeal membrane oxygenation (ECMO) in adults with severe
acute respiratory distress syndrome has increased in the past 10 years. However, the efficacy …

Noninvasive Respiratory Support in Acute Respiratory Failure Noninvasive respiratory
support can be useful for cardiogenic pulmonary edema and COPD exacerbations. For other …

The pleiotropic cytokine interleukin-6 (IL-6) has been implicated in the pathogenesis of
COVID-19, but uncertainty remains about the potential benefits and harms of targeting IL-6 …

The accuracy of the signs and tests that clinicians use to diagnose ventilator-associated
pneumonia (VAP) and initiate antibiotic treatment has not been well characterized. We sought to …

Purpose Targeted temperature management (TTM) may improve survival and functional
outcome in comatose survivors of out-of-hospital cardiac arrest (OHCA), though the optimal …