… L-alanine residues. L-alanoyl-d-glutamate endopeptidases and interpeptide bridge-specific
endopeptidases target the peptide that is composed of the L-Lysine and D-Alanine link [11]. …

… However, full resistance is achieved when the N-terminal domain is coexpressed with the
L-PG synthase domain and the L-PG is translocated to the outer layer of the membrane (96). L-…

Purpose Metastatic cervical cancer is a prototypical chemotherapy-refractory epithelial
malignancy for which better treatments are needed. Adoptive T-cell therapy (ACT) is emerging as …

The human gut contains a vast array of viruses, mostly bacteriophages. The majority remain
uncharacterized, and their roles in shaping the gut microbiome and in impacting on human …

Lantibiotics are a diverse family of bacterially synthesized antimicrobial peptides produced
by gram-positive bacteria. They usually have a broad spectrum of targets, often including …

The human gut virome is thought to significantly impact the microbiome and human health.
However, most virome analyses have been performed on a limited fraction of known viruses. …

Background Diabetes in pregnancy is associated with preterm delivery, birthweight extremes,
and increased rates of congenital anomaly, stillbirth, and neonatal death. We aimed to …

CrAssphages are an extensive and ubiquitous family of tailed bacteriophages, predicted to
infect bacteria of the order Bacteroidales. Despite being found in ~50% of individuals and …

… the process of establishing the existence of an extended family of SLS-like modified virulence
peptides (MVPs), the genetic basis for the enhanced virulence of a proportion of lineage I L…

CrAssphages represent the most abundant virus in the human gut microbiota, but the lack of
available genome sequences for comparison has kept them enigmatic. Recently, sequence-…