Elevated lactate dehydrogenase A (LDHA) expression is associated with poor outcome in
tumor patients. Here we show that LDHA-associated lactic acid accumulation in melanomas …

Cytotoxic T lymphocytes and NK cells play an important role in eliminating malignant tumor
cells and the number and activity of tumor-infiltrating T cells represent a good marker for …

Tumor-derived lactic acid inhibits T and natural killer (NK) cell function and, thereby, tumor
immunosurveillance. Here, we report that melanoma patients with high expression of …

Many tumor cells are characterized by a dysregulated glucose metabolism associated with
increased glycolysis in the presence of oxygen (“Warburg Effect”). Here, we analyzed for the …

Macrolides may cause severe drug interactions due to the inhibition of metabolizing enzymes.
Transporter-mediated uptake of drugs into cells [eg, by members of the human organic …

Increased glucose consumption distinguishes cancer cells from normal cells and is known
as the "Warburg effect" because of increased glycolysis. Lactate dehydrogenase A (LDHA) is …

The strong link between T‐cell metabolism and effector functions is well characterized in the
murine system but hardly investigated in human T cells. Therefore, we analyzed glycolytic …

Lactic acid (LA) accumulates under inflammatory conditions, eg in wounds or tumors, and
influences local immune cell functions. We previously noted inhibitory effects of LA on …

Non-steroidal anti-inflammatory drugs such as diclofenac exhibit potent anticancer effects.
Up to now these effects were mainly attributed to its classical role as COX-inhibitor. Here we …

The “glycolytic switch” also known as the “Warburg effect” is a key feature of tumor cells and
leads to the accumulation of lactate and protons in the tumor environment. Intriguingly, non‐…