[HTML][HTML] Deregulation of the EGFR/PI3K/PTEN/Akt/mTORC1 pathway in breast cancer: possibilities for therapeutic intervention
NM Davis, M Sokolosky, K Stadelman, SL Abrams… - Oncotarget, 2014 - ncbi.nlm.nih.gov
The EGFR/PI3K/PTEN/Akt/mTORC1/GSK-3 pathway plays prominent roles in malignant
transformation, prevention of apoptosis, drug resistance and metastasis. The expression of this …
transformation, prevention of apoptosis, drug resistance and metastasis. The expression of this …
Akt as a therapeutic target in cancer
LS Steelman, KM Stadelman… - Expert opinion on …, 2008 - Taylor & Francis
… This mutation results in a lysine (K) substitution for glutamic acid (E) at amino acid 17 (E17K)
in the PH domain. Cells with this Akt1 mutation have not been observed to have mutations …
in the PH domain. Cells with this Akt1 mutation have not been observed to have mutations …
[HTML][HTML] Management of gender dysphoria in adolescents in primary care
JH Bonifacio, C Maser, K Stadelman, M Palmert - Cmaj, 2019 - Can Med Assoc
We searched MEDLINE for articles published from 1950 to 2018 using the search terms “gender
dysphoria,”“gender identity,” and “transgender” and limited this search to studies …
dysphoria,”“gender identity,” and “transgender” and limited this search to studies …
Suppression of PTEN function increases breast cancer chemotherapeutic drug resistance while conferring sensitivity to mTOR inhibitors
…, WH Chappell, SL Abrams, EWT Wong, KM Stadelman… - Oncogene, 2008 - nature.com
Ectopic expression of mutant forms of phosphatase and tensin homologue deleted on
chromosome 10 (PTEN) lacking lipid (G129E) or lipid and protein (C124S) phosphatase activity …
chromosome 10 (PTEN) lacking lipid (G129E) or lipid and protein (C124S) phosphatase activity …
A phase I study of the first-in-class antimitochondrial metabolism agent, CPI-613, in patients with advanced hematologic malignancies
…, R Rodriguez, S Isom, LD Miller, KM Stadelman… - Clinical Cancer …, 2014 - AACR
Purpose: The lipoate derivative CPI-613 is a first-in-class agent that targets mitochondrial
metabolism. This study determined the effects of CPI-613 on mitochondrial function and …
metabolism. This study determined the effects of CPI-613 on mitochondrial function and …
Yin Yang 1 contains G-quadruplex structures in its promoter and 5′-UTR and its expression is modulated by G4 resolvase 1
Yin Yang 1 (YY1) is a multifunctional protein with regulatory potential in tumorigenesis. Ample
studies demonstrated the activities of YY1 in regulating gene expression and mediating …
studies demonstrated the activities of YY1 in regulating gene expression and mediating …
[HTML][HTML] Peer Reviewed: Assessing awareness and knowledge of breast and cervical cancer among Appalachian women
NL Lyttle, K Stadelman - Preventing chronic disease, 2006 - ncbi.nlm.nih.gov
… Lyttle NL, Stadelman K. Assessing awareness and knowledge of breast and cervical
cancer among Appalachian women. Prev Chronic Dis [serial online] 2006 Oct [date cited]. …
cancer among Appalachian women. Prev Chronic Dis [serial online] 2006 Oct [date cited]. …
[HTML][HTML] Involvement of Akt-1 and mTOR in sensitivity of breast cancer to targeted therapy
ML Sokolosky, KM Stadelman, WH Chappell… - Oncotarget, 2011 - ncbi.nlm.nih.gov
Elucidating the response of breast cancer cells to chemotherapeutic and hormonal based
drugs is clearly important as these are frequently used therapeutic approaches. A signaling …
drugs is clearly important as these are frequently used therapeutic approaches. A signaling …
Inhibition of GSK-3β activity can result in drug and hormonal resistance and alter sensitivity to targeted therapy in MCF-7 breast cancer cells
M Sokolosky, WH Chappell, K Stadelman, SL Abrams… - Cell cycle, 2014 - Taylor & Francis
The PI3K/Akt/mTORC1 pathway plays prominent roles in malignant transformation, prevention
of apoptosis, drug resistance, and metastasis. One molecule regulated by this pathway is …
of apoptosis, drug resistance, and metastasis. One molecule regulated by this pathway is …
Monitoring of neuromuscular blockade at the P6 acupuncture point reduces the incidence of postoperative nausea and vomiting
M Arnberger, K Stadelmann, P Alischer… - The Journal of the …, 2007 - pubs.asahq.org
Background Electrical stimulation of the P6 acupuncture point reduces the incidence of
postoperative nausea and vomiting (PONV). Neuromuscular blockade during general anesthesia …
postoperative nausea and vomiting (PONV). Neuromuscular blockade during general anesthesia …