Pituitary development: regulatory codes in mammalian organogenesis

KM Scully, MG Rosenfeld - Science, 2002 - science.org
During mammalian pituitary gland development, distinct cell types emerge from a common
primordium. Appearance of specific cell types occurs in response to opposing signaling …

Opposing LSD1 complexes function in developmental gene activation and repression programmes

J Wang, K Scully, X Zhu, L Cai, J Zhang… - Nature, 2007 - nature.com
Precise control of transcriptional programmes underlying metazoan development is modulated
by enzymatically active co-regulatory complexes, coupled with epigenetic strategies. One …

Coercive mobility and crime: A preliminary examination of concentrated incarceration and social disorganization

TR Clear, DR Rose, E Waring, K Scully - Justice Quarterly, 2003 - Taylor & Francis
… Kristen Scully is a doctoral candidate in the department of Criminology and Criminal
Justice at Florida State University. Her current research focuses on attitudes toward the justice …

The development of health care data warehouses to support data mining

JA Lyman, K Scully, JH Harrison Jr - Clinics in laboratory medicine, 2008 - Elsevier
Clinical data warehouses offer tremendous benefits as a foundation for data mining. By
serving as a source for comprehensive clinical and demographic information on large patient …

Allosteric effects of Pit-1 DNA sites on long-term repression in cell type specification

KM Scully, EM Jacobson, K Jepsen, V Lunyak… - Science, 2000 - science.org
Reciprocal gene activation and restriction during cell type differentiation from a common
lineage is a hallmark of mammalian organogenesis. A key question, then, is whether a critical …

TEF, a transcription factor expressed specifically in the anterior pituitary during embryogenesis, defines a new class of leucine zipper proteins.

DW Drolet, KM Scully, DM Simmons… - Genes & …, 1991 - genesdev.cshlp.org
We have identified and characterized a new member of the leucine zipper (bZIP) gene family
of transcription factors, thyrotroph embryonic factor (TEF). Analysis of the ontogeny of TEF …

Role of estrogen receptor-α in the anterior pituitary gland

KM Scully, AS Gleiberman, J Lindzey… - Molecular …, 1997 - academic.oup.com
Targeted insertional disruption of the mouse estrogen receptor-α (ERα) gene has provided
a genetic model in which to test hypotheses that estrogens exert important effects in …

Data mining and clinical data repositories: Insights from a 667,000 patient data set

IM Mullins, MS Siadaty, J Lyman, K Scully… - Computers in biology …, 2006 - Elsevier
… Pattern Discovery seeks to enumerate all of the associations that occur at least k times in
the data. In the second step, the patterns are clustered based on distances computed from the …

P-Lim, a LIM homeodomain factor, is expressed during pituitary organ and cell commitment and synergizes with Pit-1.

…, T Heinzel, B Gloss, KM Scully… - Proceedings of the …, 1995 - National Acad Sciences
A pituitary LIM homeodomain factor, P-Lim, is expressed as Rathke's pouch forms and as
specific pituitary cell phenotypes are established, suggesting functional roles throughout …

A tissue-specific enhancer confers Pit-1-dependent morphogen inducibility and autoregulation on the pit-1 gene.

…, R Chen, GE DiMattia, KM Scully… - Genes & …, 1993 - genesdev.cshlp.org
Pit-1 is a tissue-specific POU domain factor obligatory for the appearance of three cell phenotypes
in the anterior pituitary gland. Expression of the pit-1 gene requires the actions of a cell…