Hypoxia, a state of low oxygen, is a common feature of solid tumors and is associated with
disease progression as well as resistance to radiotherapy and certain chemotherapeutic drugs…

Light‐emitting semiconductor quantum dots (QDs) combined with magnetic resonance
imaging contrast agents within a single nanoparticle platform are considered to perform as …

We show that an end-to-end deep learning approach can be used to recognize either English
or Mandarin Chinese speech–two vastly different languages. Because it replaces entire …

Niclosamide, an oral antihelminthic drug, has been used to treat tapeworm infection for
about 50 years. Niclosamide is also used as a molluscicide for water treatment in …

Potent, specific, non-peptide small-molecule inhibitors of the MDM2−p53 interaction were
successfully designed. The most potent inhibitor (MI-63) has a K i value of 3 nM binding to …

… K i value of 300 nM, 28 times more potent than 1a. To further confirm our prediction, 1c with
a p-Cl substituent was synthesized and found to be 26 times less potent than 1b with a K … a K …

We have designed MI-219 as a potent, highly selective and orally active small-molecule
inhibitor of the MDM2–p53 interaction. MI-219 binds to human MDM2 with a K i value of 5 nM …

Gratitude is a positive psychological characteristic that is connected to well-being. The aim of
this study is to examine the effects of both social support and self-esteem in the association …

NF-κB may be a potential therapeutic target for acute myelogenous leukemia (AML) because
NF-κB activation is found in primitive human AML blast cells. In this report, we initially …

Although air quality in China has substantially improved since 2013 as a consequence of
the clean air action, severe haze events still frequently strike megacities despite strict local …