Artemisinin production in Artemisia annua: studies in planta and results of a novel delivery method for treating malaria and other neglected diseases
…, PR Arsenault, PS Covello, A McMickle, KH Teoh… - Phytochemistry …, 2011 - Springer
Artemisia annua L. produces the sesquiterpene lactone, artemisinin, a potent antimalarial
drug that is also effective in treating other parasitic diseases, some viral infections and various …
drug that is also effective in treating other parasitic diseases, some viral infections and various …
Functional genomics and the biosynthesis of artemisinin
PS Covello, KH Teoh, DR Polichuk, DW Reed… - Phytochemistry, 2007 - Elsevier
Artemisinin, a sesquiterpene lactone endoperoxide derived from the glandular secretory
trichomes (GSTs) of Artemisia annua, provides the basis for the most effective treatments of …
trichomes (GSTs) of Artemisia annua, provides the basis for the most effective treatments of …
High-level semi-synthetic production of the potent antimalarial artemisinin
…, A Tai, A Main, D Eng, DR Polichuk, KH Teoh… - Nature, 2013 - nature.com
In 2010 there were more than 200 million cases of malaria, and at least 655,000 deaths 1 .
The World Health Organization has recommended artemisinin-based combination therapies (…
The World Health Organization has recommended artemisinin-based combination therapies (…
Antithrombotic and thrombolytic therapy for valvular disease: antithrombotic therapy and prevention of thrombosis: American College of Chest Physicians Evidence …
RP Whitlock, JC Sun, SE Fremes, FD Rubens, KH Teoh - Chest, 2012 - Elsevier
Background Antithrombotic therapy in valvular disease is important to mitigate thromboembolism,
but the hemorrhagic risk imposed must be considered. Methods The methods of this …
but the hemorrhagic risk imposed must be considered. Methods The methods of this …
[HTML][HTML] Artemisia annua L.(Asteraceae) trichome-specific cDNAs reveal CYP71AV1, a cytochrome P450 with a key role in the biosynthesis of the antimalarial …
KH Teoh, DR Polichuk, DW Reed, G Nowak… - FEBS letters, 2006 - Elsevier
Artemisinin, a sesquiterpene lactone endoperoxide derived from the plant Artemisia annua,
forms the basis of the most important treatments of malaria in use today. In an effort to …
forms the basis of the most important treatments of malaria in use today. In an effort to …
[HTML][HTML] The molecular cloning of artemisinic aldehyde Δ11 (13) reductase and its role in glandular trichome-dependent biosynthesis of artemisinin in Artemisia annua
Y Zhang, KH Teoh, DW Reed, L Maes… - Journal of Biological …, 2008 - ASBMB
At some point during biosynthesis of the antimalarial artemisinin in glandular trichomes of
Artemisia annua, the Δ11(13) double bond originating in amorpha-4,11-diene is reduced. This …
Artemisia annua, the Δ11(13) double bond originating in amorpha-4,11-diene is reduced. This …
Methylprednisolone in patients undergoing cardiopulmonary bypass (SIRS): a randomised, double-blind, placebo-controlled trial
RP Whitlock, PJ Devereaux, KH Teoh, A Lamy… - The Lancet, 2015 - thelancet.com
Background Cardiopulmonary bypass initiates a systemic inflammatory response syndrome
that is associated with postoperative morbidity and mortality. Steroids suppress inflammatory …
that is associated with postoperative morbidity and mortality. Steroids suppress inflammatory …
Molecular cloning of an aldehyde dehydrogenase implicated in artemisinin biosynthesis in Artemisia annua
KH Teoh, DR Polichuk, DW Reed, PS Covello - Botany, 2009 - cdnsciencepub.com
Limitations in the supply of the antimalarial compound artemisinin from Artemisia annua L.
have led to an interest in understanding its biosynthesis and enhancing its production. Recent …
have led to an interest in understanding its biosynthesis and enhancing its production. Recent …
Accelerated myocardial metabolic recovery with terminal warm blood cardioplegia
KH Teoh, GT Christakis, RD Weisel, SE Fremes… - The Journal of thoracic …, 1986 - Elsevier
Although blood cardioplegia provides excellent protection, myocardial metabolic recovery is
delayed. To evaluate the benefits of a terminal warm cardioplegic infusion after cold blood …
delayed. To evaluate the benefits of a terminal warm cardioplegic infusion after cold blood …
Capacitive behavior studies on electrical double layer capacitor using poly (vinyl alcohol)–lithium perchlorate based polymer electrolyte incorporated with TiO2
Electric double layer capacitors (EDLCs) based on activated carbon electrodes and poly (vinyl
alcohol)–lithium perchlorate (PVA–LiClO 4 )-nanosized titania (TiO 2 ) doped polymer …
alcohol)–lithium perchlorate (PVA–LiClO 4 )-nanosized titania (TiO 2 ) doped polymer …