OBJECTIVE: To develop and validate a single numerical comorbidity score for predicting
short- and long-term mortality, by combining conditions in the Charlson and Elixhauser …

Background/Objective: Anti-inflammatory drugs may prevent Parkinson disease (PD) by
inhibiting a putative underlying neuroinflammatory process. We tested the hypothesis that anti-…

OBJECTIVE: To develop and validate a maternal comorbidity index to predict severe maternal
morbidity, defined as the occurrence of acute maternal end-organ injury, or mortality. …

Recent theoretical studies have shown that conditioning on an instrumental variable (IV), a
variable that is associated with exposure but not associated with outcome except through …

Background: Many epidemiologic studies have considered the association between blood
pressure (BP) and Alzheimer disease, yet the relationship remains poorly understood. …

Background: The automatic substitution of bioequivalent generics for brand-name antiepileptic
drugs (AEDs) has been linked by anecdotal reports to loss of seizure control. Objective: …

Purpose Defining a study population and creating an analytic dataset from longitudinal
healthcare databases involves many decisions. Our objective was to catalogue scientific …

… Joshua J Gagne assistant professor, Lauren Thompson research assistant, Kelly O’Keefe
research … 4 Kesselheim AS, Gagne JJ. Strategies for post-market surveillance of drugs for rare …

Background: Statins are effective in preventing cardiovascular events, but patients do not
fully adhere to them. Objective: To determine whether patients are more adherent to generic …

Background— Dabigatran, an oral thrombin inhibitor, and rivaroxaban and apixaban, oral
factor Xa inhibitors, have been found to be safe and effective in reducing stroke risk in patients …