Introduction: Current treatment of osteosarcoma includes surgical resection of all gross
disease in conjunction with systemic chemotherapy to control micro-metastatic disease. This …

Immunoconjugates targeting cell-surface antigens have demonstrated clinical activity to enable
regulatory approval in several solid and hematologic malignancies. We hypothesize that …

What's known on the subject? and What does the study add? One of the main components of
surgical training is the development of operative skills which, in part, is related to the extent …

Background Regorafenib is a small molecule multikinase inhibitor that inhibits multiple
kinases including BRAF, KIT, PDGFRB, RAF, RET, and VEGFR1‐3. Procedures The in vivo …

Extra-gonadal yolk sac tumors (YSTs) are rare and generally associated with poor outcomes.
Involvement of the seminal vesicles is extremely rare with only one previously described …

Orthotopic bladder reconstruction is becoming increasingly popular in patients who have
undergone radical cystectomy. One of the rare complications is spontaneous rupture, which …

A 64-year-old man presents to his primary care physician with a six-month history of frequent
urination during the night. The patient reports having no such symptoms during the day. His …

Calcium signals, pivotal in controlling cell function, can be generated by calcium entry
channels activated by plasma membrane depolarization or depletion of internal calcium stores. …

The first non-beta release of the Weather Research and Forecast (WRF) modeling system in
May, 2004 represented a key milestone in the effort to design and implement a fully-…

A 68 year old man presented with a large scrotal swelling, and ultrasound scanning suggested
a hydrocele. He was subsequently admitted with renal failure, and computed tomography…