Objective To provide an update to “Surviving Sepsis Campaign Guidelines for Management
of Sepsis and Septic Shock: 2012”. Design A consensus committee of 55 international …

Importance Definitions of sepsis and septic shock were last revised in 2001. Considerable
advances have since been made into the pathobiology (changes in organ function, …

Objective In 2003, critical care and infectious disease experts representing 11 international
organizations developed management guidelines for severe sepsis and septic shock that …

Importance Effective therapies for patients with coronavirus disease 2019 (COVID-19) are
needed, and clinical trial data have demonstrated that low-dose dexamethasone reduced …

… Organ dysfunction can be defined using the definitions developed by Marshall et al. ( 19 )
or the definitions used for the Sequential Organ Failure Assessment (SOFA) score ( 20 ). …

… Marshall); Department of Medicine, McMaster University, Hamilton, ON, Canada (Dr.
Cook); Department of Surgery, McGill University, Montreal, PQ, Canada (Dr. Christou); …

People with COVID-19 might have sustained postinfection sequelae. Known by a variety of
names, including long COVID or long-haul COVID, and listed in the ICD-10 classification as …

Background The efficacy of interleukin-6 receptor antagonists in critically ill patients with
coronavirus disease 2019 (Covid-19) is unclear. Methods We evaluated tocilizumab and …

Clinical research is necessary for an effective response to an emerging infectious disease
outbreak. However, research efforts are often hastily organised and done using various …

Objective The Surviving Sepsis Campaign (SSC or “the Campaign”) developed guidelines
for management of severe sepsis and septic shock. A performance improvement initiative …