Wildlife reservoirs of broad-host-range viruses have the potential to enable evolution of viral
variants that can emerge to infect humans. In North America, there is phylogenomic …

Generalist and specialist species differ in the breadth of their ecological niches. Little is known
about the niche width of obligate human pathogens. Here we analyzed a global collection …

Whole genome sequencing (WGS) of Mycobacterium tuberculosis has rapidly progressed
from a research tool to a clinical application for the diagnosis and management of tuberculosis …

Wildlife reservoirs of SARS-CoV-2 can lead to viral adaptation and spillback from wildlife to
humans ( Oude Munnink et al., 2021 ). In North America, there is evidence of spillover of …

Background Bedaquiline is a core drug for the treatment of multidrug-resistant tuberculosis;
however, the understanding of resistance mechanisms is poor, which is hampering rapid …

Pyrazinamide (PZA) is an important component of first-line therapy for the treatment of
tuberculosis. Here, we evaluate targeted gene sequencing as a supplement to phenotypic PZA …

Patterns of gene flow can have marked effects on the evolution of populations. To better
understand the migration dynamics of Mycobacterium tuberculosis, we studied genetic data from …

Background: Co-infections of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
with respiratory viruses, bacteria and fungi have been reported to cause a wide range of …

Genomics is now firmly established as a technique for the investigation and reconstruction
of communicable disease outbreaks, with many genomic epidemiology studies focusing on …

Background Understanding regional molecular epidemiology allows for the development of
more efficient tuberculosis prevention strategies in low-incidence settings. Methods We …