Advanced and metastatic tumors with complex treatment histories drive cancer mortality.
Here we describe the POG570 cohort, a comprehensive whole-genome, transcriptome and …

Importance A molecular diagnostic method that incorporates information about the transcriptional
status of all genes across multiple tissue types can strengthen confidence in cancer …

Using the 2016 recommendations of the Canadian Task Force on Cannabis Legalization
and Regulation as a guide, the amended regulation that legalizes edibles aims to address …

Background Precision oncology involves analysis of individual cancer samples to understand
the genes and pathways involved in the development and progression of a cancer. To …

To model biological systems that undergo change, it is not strictly necessary to know the
details of the underlying mechanisms. Instead, we can model change as a series of transitions …

In the August issue of Nature Methods, we used a Markov chain to model a dynamic system
by a series of probabilistic transitions between states1. We showed that the long-term …

Pancreatic neuroendocrine neoplasms (PanNENs) represent a minority of pancreatic
neoplasms that exhibit variability in prognosis. Ongoing mutational analyses of PanNENs have …

In this study, we evaluate the impact of whole genome and transcriptome analysis (WGTA)
on predictive molecular profiling and histologic diagnosis in a cohort of advanced …

PURPOSE This study investigated therapeutic potential of integrated genome and
transcriptome profiling of metastatic sarcoma, a rare but extremely heterogeneous group of …

Thyroid-like follicular renal cell carcinoma (TLFRCC) is a rare cancer with few reports of
metastatic disease. Little is known regarding genomic characteristics and therapeutic targets. …