Objective To determine all cause mortality and deaths from cardiovascular events related to
intensive glucose lowering treatment in people with type 2 diabetes. Design Meta-analysis …

Background This is the first update of a review published in 2009. Sustained moderate to
severe elevations in resting blood pressure leads to a critically important clinical question: …

Background: The annual cut-off date of birth for entry to school in British Columbia, Canada,
is Dec. 31. Thus, children born in December are typically the youngest in their grade. We …

Background People with no previous cardiovascular events or cardiovascular disease
represent a primary prevention population. The benefits and harms of treating mild hypertension …

Background When treating elevated blood pressure, doctors need to know what blood pressure
(BP) target they should try to achieve. The standard of clinical practice for some time has …

Background Elevated blood pressure (known as hypertension) increases with age, and most
rapidly over age 60. Systolic hypertension is more strongly associated with cardiovascular …

A review of statins for primary prevention of cardiovascular disease could alter guidance for
those with a 10 year risk of less than 10%. John Abramson and colleagues argue that statins …

Background— Bias in studies of preventive medications can occur when healthier patients
are more likely to initiate and adhere to therapy than less healthy patients. We sought …

Background Hypertension is a modifiable cardiovascular risk factor. Although it is established
that low‐dose thiazides reduce mortality as well as cardiovascular morbidity, the dose‐…

Background Results of randomized controlled trials are consistent in showing reduced rates
of stroke, heart failure and cardiovascular events in very old patients treated with …