Highly variable drugs' have been defined as those drugs for which the within-subject variability
(WSV) equals or exceeds 30% of the maximum concentration (C max ) and/or the area …

Addressing the need for research on the nature of refractoriness to antipsychotic drug
therapy exhibited by a substantial minority of schizophrenic patients, Philip RA May and Sven …

… Lim HK, Hubbard JW, Midha KK. Development of enantioselective gas chromatographic
quantitation assay for dl-threo-methylphenidate in biological fluids. J Chromatogr l986;378: 109-…

Following a 2-week placebo lead-in, schizophrenic patients were randomly assigned to
fluoxetine 20 mg/day or placebo added to depot neuroleptic for a 6-week, double blind trial. All …

A study was carried out in 11 healthy young men to investigate the pharmacokinetics of
chlorpromazine (CPZ) after a bolus intravenous (IV) dose (10 mg) and three single oral doses (25…

… McKay, MJ Rawson, ED Korchinski, and JW Hubbard. Effects of food on the pharmacokinetics
of … YZ Shu, JW Hubbard, JK Cooper, G. McKay, ED Korchinski, R. Kumar, and KK Midha. …

… HK Lim, JW Hubbard, and KK Midha. Development of enantioselective gas … NR
Srinivas, JW Hubbard, and KK Midha. Enantioselective gas chromatographic assay with …

We describe systematic studies on Nd and Mn co-doped BiFeO 3, ie,(Bi 0.95 Nd 0.05)(Fe 0.97
Mn 0.03) O 3 (BNFM) polycrystalline electroceramics. Raman spectra and X-ray diffraction …

The authors review the literature regarding the pharmacokinetics of long-acting injectable
neuroleptic drugs (LINS). There are important differences between LINS and oral neurolepties …

Purpose. To establish procedures for the effective evaluation of bioequivalence (BE) for
highly-variable drugs and drug products (HVD/P). Methods. 2- and 4-period crossover BE …