User profiles for J. Sirois

Jean Sirois

- Verified email at umontreal.ca - Cited by 9138

Jacinthe Sirois

- Verified email at mcgill.ca - Cited by 1798

TASK-1 is a highly modulated pH-sensitive 'leak'K+ channel expressed in brainstem respiratory neurons

DA Bayliss, EM Talley, JE Sirois, Q Lei - Respiration physiology, 2001 - Elsevier
Central respiratory chemoreceptors adjust respiratory drive in a homeostatic response to
alterations in brain pH and/or P CO 2 . Multiple brainstem sites are proposed as neural …

Two-pore-Domain (KCNK) potassium channels: dynamic roles in neuronal function

EM Talley, JE Sirois, Q Lei, DA Bayliss - The Neuroscientist, 2003 - journals.sagepub.com
Leak K + currents contribute to the resting membrane potential and are important for modulation
of neuronal excitability. Within the past few years, an entire family of genes has been …

[HTML][HTML] The TASK family: two-pore domain background K+ channels

DA Bayliss, JE Sirois, EM Talley - Molecular Interventions, 2003 - triggered.clockss.org
The recent identification of a distinct family of genes encoding two-pore domain potassium
channels that generate background, or leak, K+ currents has permitted the analysis of the …

[PDF][PDF] TASK-1, a two–pore domain K+ channel, is modulated by multiple neurotransmitters in motoneurons

EM Talley, Q Lei, JE Sirois, DA Bayliss - Neuron, 2000 - cell.com
Inhibition of "leak" potassium (K + ) channels is a widespread CNS mechanism by which
transmitters induce slow excitation. We show that TASK-1, a two pore domain K + channel, …

The TASK-1 two-pore domain K+ channel is a molecular substrate for neuronal effects of inhalation anesthetics

JE Sirois, Q Lei, EM Talley, C Lynch… - Journal of …, 2000 - Soc Neuroscience
Despite widespread use of volatile general anesthetics for well over a century, the mechanisms
by which they alter specific CNS functions remain unclear. Here, we present evidence …

Ovarian follicular dynamics during the estrous cycle in heifers monitored by real-time uitrasonograph

J Sirois, JE Fortune - Biology of reproduction, 1988 - academic.oup.com
It is not clear whether the turnover of ovarian follicles during the estrous cycle in cattle is
continuous and independent of the phase of the cycle, or whether waves of follicular growth …

Serotonergic raphe neurons express TASK channel transcripts and a TASK-like pH-and halothane-sensitive K+ conductance

CP Washburn, JE Sirois, EM Talley… - Journal of …, 2002 - Soc Neuroscience
The recently described two-pore-domain K + channels, TASK-1 and TASK-3, generate
currents with a unique set of properties; specifically, the channels produce instantaneous open-…

Lengthening the bovine estrous cycle with low levels of exogenous progesterone: a model for studying ovarian follicular dominance

J Sirois, JE Fortune - Endocrinology, 1990 - academic.oup.com
In cattle the development of ovarian follicles ≥5 mm occurs in waves, with either two or three
waves per estrous cycle. To increase our understanding of the control of follicular dynamics …

Targeted ablation of the 25-hydroxyvitamin D 1α-hydroxylase enzyme: evidence for skeletal, reproductive, and immune dysfunction

…, D Miao, ML Tremblay, J Sirois… - Proceedings of the …, 2001 - National Acad Sciences
… Genomic organization of the mouse 1α(OH)ase region was determined by cloning the gene
from a 129sv/J library as described (17). (B) Analysis of genomic DNA isolated from pups …

Prostaglandin biosynthesis, transport, and signaling in corpus luteum: a basis for autoregulation of luteal function

…, SK Banu, P Chapdelaine, E Madore, J Sirois… - …, 2004 - academic.oup.com
The corpus luteum (CL) is a transient ovarian endocrine gland formed from the ovulated follicle.
Progesterone is the primary secretory product of CL and is essential for establishment of …