Apolipoprotein E (apoE) is critical in the modulation of cholesterol and phospholipid transport
between cells of different types. Human apoE is a polymorphic protein with three common …

Proteolytic processing of amyloid precursor protein (APP) through an endosomal/lysosomal
pathway generates carboxy-terminal polypeptides that contain an intact β-amyloid domain 1…

The scrapie agent protein (Sp33-37 or PrPSC) is the disease-associated isoform of a normal
cellular membrane protein (Cp33-37 or PrPc) of unknown function. We report that normal …

Heat shock protein 70 (Hsp70) protects cultured motor neurons from the toxic effects of
mutations in Cu/Zn-superoxide dismutase (SOD-1), which is responsible for a familial form of the …

In solid tumors, cancer cells subjected to ischemic conditions trigger distinct signaling pathways
contributing to angiogenic stimulation and tumor development. Characteristic features of …

… HOWELL, S., J. NALBANTOGLU AND P. CRINE. Neutral endopeptidase can hydrolyze P-atnyZoid(l-40)
but shows no effect on @… HOWELL, NALBANTOGLU AND CRINE …

Intramuscular injection of plasmid is a potential alternative to viral vectors for the transfer of
therapeutic genes into skeletal muscle fibers. The low efficiency of plasmid-based gene …

High threshold for stress-induced activation of the heat shock transcription factor, Hsf1, may
contribute to vulnerability of motor neurons to disease and limit efficacy of agents promoting …

Utrophin is a close homolog of dystrophin, the protein whose mutations cause Duchenne
muscular dystrophy (DMD). Utrophin is present at low levels in normal and dystrophic muscle, …

Multiple sclerosis (MS) is a neurological disorder characterized by myelin destruction and a
variable degree of oligodendrocyte death. We have previously shown that overexpression of …