Objective. —To determine whether a program incorporating smoking intervention and use
of an inhaled bronchodilator can slow the rate of decline in forced expiratory volume in 1 …

The effects of broad-spectrum antibiotic and placebo therapy in patients with chronic
obstructive pulmonary disease in exacerbation were compared in a randomized, double-blinded, …

Background: Randomized clinical trials have not yet demonstrated the mortality benefit of
smoking cessation. Objective: To assess the long-term effect on mortality of a randomly applied …

PURPOSE: Atrial fibrillation is a common arrhythmia associated with increased cardiovascular
morbidity and mortality. This study was undertaken to identify the natural history of this …

This report deals with deaths and hospitalizations during the 5-year Lung Health Study, as
documented by examination of appropriate records. There were 149 deaths (2.5%) during the …

Background Current knowledge of risk factors for Alzheimer's disease (AD) is limited. Data
from a longitudinal, population-based study of dementia in Manitoba, Canada were used to …

Obstructive sleep apnea syndrome (OSAS) patients may have symptoms for years prior to
recognition of their disorder, or they may be treated for the associated comorbidities. We …

Background Patients with obstructive sleep apnea syndrome (OSAS) use health-care resources
at higher rates than control subjects for years prior to diagnosis. Although obesity and …

… Stradling J. Sleep apnea and the misuse of evidence-based medicine. Lancet 1997;349:201…
Ronald J, Delaive K, Roos L, Manfreda J, Bahammam A, Kryger M. Health care utilization in …

Objective To document health-care utilization (ie, physician claims and hospitalizations) in
patients with obesity-hypoventilation syndrome (OHS), for 5 years prior to the diagnosis and …