Genome-scale models of microbial cells: evaluating the consequences of constraints

ND Price, JL Reed, BØ Palsson - Nature Reviews Microbiology, 2004 - nature.com
Microbial cells operate under governing constraints that limit their range of possible
functions. With the availability of annotated genome sequences, it has become possible to …

Reconstruction of biochemical networks in microorganisms

AM Feist, MJ Herrgård, I Thiele, JL Reed… - Nature Reviews …, 2009 - nature.com
Abstract Systems analysis of metabolic and growth functions in microbial organisms is
rapidly developing and maturing. Such studies are enabled by reconstruction, at the genomic …

Towards environmental systems biology of Shewanella

…, AL Osterman, G Pinchuk, JL Reed… - Nature Reviews …, 2008 - nature.com
Bacteria of the genus Shewanella are known for their versatile electron-accepting capacities,
which allow them to couple the decomposition of organic matter to the reduction of the …

A genome‐scale metabolic reconstruction for Escherichia coli K‐12 MG1655 that accounts for 1260 ORFs and thermodynamic information

AM Feist, CS Henry, JL Reed… - Molecular systems …, 2007 - embopress.org
An updated genome‐scale reconstruction of the metabolic network in Escherichia coli K‐12
MG1655 is presented. This updated metabolic reconstruction includes: (1) an alignment with …

An expanded genome-scale model of Escherichia coli K-12 (iJR904 GSM/GPR)

JL Reed, TD Vo, CH Schilling, BO Palsson - Genome biology, 2003 - Springer
Background Diverse datasets, including genomic, transcriptomic, proteomic and metabolomic
data, are becoming readily available for specific organisms. There is currently a need to …

Integrating high-throughput and computational data elucidates bacterial networks

MW Covert, EM Knight, JL Reed, MJ Herrgard… - Nature, 2004 - nature.com
The flood of high-throughput biological data has led to the expectation that computational (or
in silico) models can be used to direct biological discovery, enabling biologists to reconcile …

Mast cells are essential intermediaries in regulatory T-cell tolerance

…, K Pino-Lagos, ZA Scott, AJ Coyle, JL Reed… - Nature, 2006 - nature.com
Contrary to the proinflammatory role of mast cells in allergic disorders, the results obtained
in this study establish that mast cells are essential in CD4 + CD25 + Foxp3 + regulatory T (T …

MEDI-563, a humanized anti–IL-5 receptor α mAb with enhanced antibody-dependent cell-mediated cytotoxicity function

…, CK Andersson, MM Damschroder, JL Reed… - Journal of Allergy and …, 2010 - Elsevier
BACKGROUND: Peripheral blood eosinophilia and lung mucosal eosinophil infiltration are
hallmarks of bronchial asthma. IL-5 is a critical cytokine for eosinophil maturation, survival, …

Severe human lower respiratory tract illness caused by respiratory syncytial virus and influenza virus is characterized by the absence of pulmonary cytotoxic …

…, PL Ogra, LA McKinney, JL Reed… - The Journal of …, 2007 - academic.oup.com
Background. Respiratory syncytial virus (RSV) and influenza virus are common causes of
infantile lower respiratory tract infection (LRTI). It is widely believed that both viral replication …

[BOOK][B] In search of Paul: How Jesus's Apostle opposed Rome's Empire with God's Kingdom: a new vision of Paul's words & world

JD Crossan, JL Reed - 2004 - academia.edu
… Jonathan Reed - Böcker Bokus bokhandel . and Jonathan L. Reed: In Search Of Paul:
How Jesus's Apostle Opposed Rome's Empire With God's Kingdom—A New Vision Of …