A major obstacle to successful islet transplantation for both type 1 and 2 diabetes is an
inadequate supply of insulin-producing tissue. This need for transplantable human islets has …

Diabetes is a chronic debilitating disease that results from insufficient production of insulin
from pancreatic β-cells. Islet cell replacement can effectively treat diabetes but is currently …

The nonobese diabetic mouse is a model of spontaneous type I diabetes mellitus. It is
possible to induce diabetes in young, irradiated nonobese diabetic mice by using adoptive …

We describe a new technique for microencapsulation with high–mannuronic acid (high-M)
alginate crosslinked with BaCl 2 without a traditional permselective component, which allows …

Human embryonic stem cells (hESCs) are considered a potential alternative to cadaveric
islets as a source of transplantable cells for treating patients with diabetes. We previously …

Aims/hypothesis Islet transplantation is a promising cell therapy for patients with diabetes,
but it is currently limited by the reliance upon cadaveric donor tissue. We previously …

Using transgenic mice that express a constitutively active version of STAT5b, we demonstrate
that STAT5 plays a key role in governing B cell development and T cell homeostasis. …

The aim of this study was to test whether an omental pouch can be used as an alternative
site for islet implantation in diabetic monkeys. Here we report the successful engraftment of …

Objective: To assess the effects of exposure to 4% and 6% carboxyhemoglobin on ventricular
arrhythmias in patients with coronary artery disease. Design: Randomized, double-blind, …

Despite improvements in outcomes for human islet transplantation, characterization of islet
preparations remains poorly defined. This study used both light microscopy (LM) and electron …