p38 MAP kinases: key signalling molecules as therapeutic targets for inflammatory diseases

S Kumar, J Boehm, JC Lee - Nature reviews Drug discovery, 2003 - nature.com
Lee, JC et al. A protein kinase involved in the regulation of inflammatory cytokine … &
Lee, JC p38 MAP kinase: molecular target for the inhibition of pro-inflammatory cytokines. …

EGFR Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib Therapy

JG Paez, PA Janne, JC Lee, S Tracy, H Greulich… - Science, 2004 - science.org
Receptor tyrosine kinase genes were sequenced in non–small cell lung cancer (NSCLC)
and matched normal tissue. Somatic mutations of the epidermal growth factor receptor gene …

Staphylococcus aureus Capsular Polysaccharides

K O'Riordan, JC Lee - Clinical microbiology reviews, 2004 - Am Soc Microbiol
… CY Lee's laboratory sequenced the cap8 gene cluster, and the laboratories of TJ Foster and
JC Lee sequenced the cap5 gene cluster. The cap5 and cap8 loci are allelic and comprise …

Inhibition of p38 MAP kinase as a therapeutic strategy

JC Lee, S Kumar, DE Griswold, DC Underwood… - …, 2000 - Elsevier
Since the discovery of p38 MAP kinase in 1994, our understanding of its biology has progressed
dramatically. The key advances include (1) identification of p38 MAP kinase homologs …

Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease

…, RH Duerr, DP McGovern, KY Hui, JC Lee… - Nature, 2012 - nature.com
Crohn’s disease and ulcerative colitis, the two common forms of inflammatory bowel disease
(IBD), affect over 2.5 million people of European ancestry, with rising prevalence in other …

Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47

…, CW Lees, A Franke, M D'Amato, KD Taylor, JC Lee… - Nature …, 2011 - nature.com
Genome-wide association studies and candidate gene studies in ulcerative colitis have
identified 18 susceptibility loci. We conducted a meta-analysis of six ulcerative colitis genome-…

Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease

KM De Lange, L Moutsianas, JC Lee, CA Lamb… - Nature …, 2017 - nature.com
Genetic association studies have identified 215 risk loci for inflammatory bowel disease 1 ,
2 , 3 , 4 , 5 , 6 , 7 , 8 , thereby uncovering fundamental aspects of its molecular biology. We …

An oral SARS-CoV-2 Mpro inhibitor clinical candidate for the treatment of COVID-19

…, BL Hurst, EP Kadar, AS Kalgutkar, JC Lee, J Lee… - Science, 2021 - science.org
The worldwide outbreak of COVID-19 caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) has become a global pandemic. Alongside vaccines, antiviral …

[HTML][HTML] Inherited determinants of Crohn's disease and ulcerative colitis phenotypes: a genetic association study

…, DPB McGovern, JC Barrett, CW Lees - The Lancet, 2016 - thelancet.com
Background Crohn's disease and ulcerative colitis are the two major forms of inflammatory
bowel disease; treatment strategies have historically been determined by this binary …

Measurements of Ω and Λ from 42 high-redshift supernovae

…, IM Hook, AG Kim, MY Kim, JC Lee… - The Astrophysical …, 1999 - iopscience.iop.org
We report measurements of the mass density, Ω $\mathstrut {_ {M}} $, and cosmological-constant
energy density, Ω $\mathstrut {_ {{\Lambda}}} $, of the universe based on the analysis …