Objectives In view of the critical role of intracellular Ca 2+-overload in the genesis of myocyte
dysfunction and the ability of reactive oxygen species (ROS) to induce the intracellular Ca 2…

Background: Myocardial ischemia–reperfusion represents a clinically relevant problem
associated with thrombolysis, angioplasty and coronary bypass surgery. Injury of myocardium …

Purpose To review the reliability and validity of the CAGE questionnaire across different
patient populations and discuss its role in the detection of alcohol-related problems. Methods …

We describe the landscape of genomic alterations in cutaneous melanomas through DNA,
RNA, and protein-based analysis of 333 primary and/or metastatic melanomas from 331 …

Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer. Here, we
describe the genomic landscape of 496 PTCs. We observed a low frequency of somatic …

There is substantial heterogeneity among primary prostate cancers, evident in the spectrum
of molecular abnormalities and its variable clinical course. As part of The Cancer Genome …

Genetic alterations in signaling pathways that control cell-cycle progression, apoptosis, and
cell growth are common hallmarks of cancer, but the extent, mechanisms, and co-…

For a decade, The Cancer Genome Atlas (TCGA) program collected clinicopathologic
annotation data along with multi-platform molecular profiles of more than 11,000 human tumors …

Primary triple-negative breast cancers (TNBCs), a tumour type defined by lack of oestrogen
receptor, progesterone receptor and ERBB2 gene amplification, represent approximately 16…

We report a comprehensive analysis of 412 muscle-invasive bladder cancers characterized
by multiple TCGA analytical platforms. Fifty-eight genes were significantly mutated, and the …