A six week old infant with acute leukemia failed to attain remission with chemotherapy.
Because we previously demonstrated that the iron chelator deferoxamine (DFO) has …

… Here, we have used expression profiling for the identification of important genes/pathways
involved in FL transformation. We studied an initial cohort of matched pairs of FLs and their …

Acquired chromosomal rearrangements in acute nonlymphocytic leukemia (ANLL) have
been linked to specific clinicopathologic features that suggest new disease subtypes. In this …

Previous studies of oral cancer have suggested that alterations of the p53 tumour suppressor
gene occur early in the precancerous stage of development. However, these observations …

… Comparison with murine HOX-2.6, for example, showed identity or conservative changes at
… Furthermore, there was identity at 13 of the 17 amino acids that are less strictly conserved in …

… Dube is scientific director of the Gene Therapy Program (hematology/oncology), Toronto
Hospital, and associate professorofpathologyand pediatrics, Universityof Toronto, Toronto, Ont. …

… In this study we infused five homozygous affected α-ID–deficient pups with autologous
marrow genetically corrected to express high levels of functional α-ID. Our results demonstrate …

HOX11, a human homeobox gene with putative oncogenic potential, was originally discovered
at the chromosome 10 breakpoint in T-cell acute lymphoblastic leukemias bearing the …

Retroviral infection of bone marrow cells in long-term marrow cultures (LTMCs) offers several
theoretical advantages over other methods for gene transfer into hematopoietic stem cells. …

… When study of the t(5;17) APL translocation began, the identity of the RARα fusion partner
was unknown. Due to limited patient material, somatic cell hybrid lines were established and …