Inhibiting PD-L1 palmitoylation enhances T-cell immune responses against tumours

H Yao, J Lan, C Li, H Shi, JP Brosseau… - Nature biomedical …, 2019 - nature.com
Checkpoint blockade therapy targeting the programmed-death ligand 1 (PD-L1) and its
receptor programmed cell death 1 promotes T-cell-mediated immunosurveillance against …

[HTML][HTML] Cancer cell-intrinsic PD-1 and implications in combinatorial immunotherapy

H Yao, H Wang, C Li, JY Fang, J Xu - Frontiers in immunology, 2018 - frontiersin.org
Programmed death 1 (PD-1) and its two natural ligands PD-L1 and PD-L2 are responsible
for delivering inhibitory signals that regulate the balance between T cell activation, tolerance, …

HIP1R targets PD-L1 to lysosomal degradation to alter T cell–mediated cytotoxicity

H Wang, H Yao, C Li, H Shi, J Lan, Z Li… - Nature chemical …, 2019 - nature.com
Expression of programmed cell death 1 (PD-1) ligand 1 (PD-L1) protects tumor cells from T
cell–mediated immune surveillance, and immune checkpoint blockade (ICB) therapies …

Anterior cingulate cortex dysfunction underlies social deficits in Shank3 mutant mice

…, J Chen, Q Chen, K Ren, D Feng, H Mao, H Yao… - Nature …, 2019 - nature.com
Social deficit is a core clinical feature of autism spectrum disorder (ASD) but the underlying
neural mechanisms remain largely unclear. We demonstrate that structural and functional …

Circular dichroism in functional quality evaluation of medicines

H Yao, E Wynendaele, X Xu, A Kosgei… - … of Pharmaceutical and …, 2018 - Elsevier
Circular dichroism (CD) is a non-destructive and powerful technique for providing structure
and ligand interaction information of small molecules as well as biotechnological medicines. …

[HTML][HTML] Transversus abdominis plane block: an updated review of anatomy and techniques

…, TY Chuang, SF Yang, CC Chang, HY Yao… - BioMed research …, 2017 - hindawi.com
Purpose of Review. Transversus abdominis plane (TAP) block is a regional technique for
analgesia of the anterolateral abdominal wall. This review highlights the nomenclature system …

Skeletal muscle cell proliferation and differentiation on polypyrrole substrates doped with extracellular matrix components

KJ Gilmore, M Kita, Y Han, A Gelmi, MJ Higgins… - Biomaterials, 2009 - Elsevier
Conducting polymers have been developed as substrates for in vitro studies with a range of
cell types including electrically-excitable cells such as nerve and smooth muscle. The goal …

[HTML][HTML] Regulation of PD-L1: emerging routes for targeting tumor immune evasion

Y Wang, H Wang, H Yao, C Li, JY Fang… - Frontiers in …, 2018 - frontiersin.org
Immune checkpoint blockade therapies (ICBTs) targeting programmed cell death 1 (PD-1)
and its ligand programmed death ligand-1 (PD-L1/B7-H1/CD274) have exhibited momentous …

[HTML][HTML] Engineering the heart: evaluation of conductive nanomaterials for improving implant integration and cardiac function

…, H Sun, X Qiu, Y Mou, Z Liu, Y Zhao, X Li, Y Han… - Scientific reports, 2014 - nature.com
Recently, carbon nanotubes together with other types of conductive materials have been
used to enhance the viability and function of cardiomyocytes in vitro. Here we demonstrated a …

Porous anorthite ceramics with ultra-low thermal conductivity

Y Han, C Li, C Bian, S Li, CA Wang - Journal of the European Ceramic …, 2013 - Elsevier
Porous anorthite ceramics with an ultra-low thermal conductivity of 0.018W/mK have been
fabricated by hydrous foam-gelcasting process and pressureless sintering method using γ-…