OBJECTIVE: Current estimates of the prevalence of depression during pregnancy vary widely.
A more precise estimate is required to identify the level of disease burden and develop …

Depression during pregnancy is common, affecting an estimated 20% of women. However,
conflicting data exist concerning the outcomes of this disorder. Thus, we reviewed studies …

Ascertaining the impact of uncharacterized perturbations on the cell is a fundamental problem
in biology. Here, we describe how a single assay can be used to monitor hundreds of …

Genome-wide transcript profiling was used to monitor signal transduction during yeast
pheromone response. Genetic manipulations allowed analysis of changes in gene expression …

We describe here a method for drug target validation and identification of secondary drug
target effects based on genome-wide gene expression patterns. The method is demonstrated …

Background: Insulin analogues may be associated with fewer episodes of hypoglycemia
than conventional insulins. However, they are costly alternatives. We compared the cost-…

Introduction Exenatide is a glucagon-like peptide-1 receptor agonist (GLP-1 RA), approved
for treatment of type 2 diabetes mellitus (T2DM). There is limited direct evidence comparing …

Background The purpose of this constructivist grounded theory study was to develop a
theoretical model that explains women's processes of managing diagnosed depression when …

[en] A simple, easy to use method, called Estimate of Adversary Sequence Interruption (EASI),
has been developed to evaluate physical security system performance under specified …

Aims The efficacy and safety of sodium–glucose linked transporters (SGLT2s) plus metformin
and a sulfonylurea (MET + SU) for the treatment of type 2 diabetes mellitus (T2DM) in …