Phagosomes are competent organelles for antigen cross-presentation

M Houde, S Bertholet, E Gagnon, S Brunet, G Goyette… - Nature, 2003 - nature.com
The ability to process microbial antigens and present them at the surface of cells is an important
aspect of our innate ability to clear infections. It is generally accepted that antigens in the …

[HTML][HTML] Divergent SARS-CoV-2 variant emerges in white-tailed deer with deer-to-human transmission

…, O Vernygora, E Adey, M Nebroski, G Goyette… - Nature …, 2022 - nature.com
Wildlife reservoirs of broad-host-range viruses have the potential to enable evolution of viral
variants that can emerge to infect humans. In North America, there is phylogenomic …

[PDF][PDF] A single dose of the SARS-CoV-2 vaccine BNT162b2 elicits Fc-mediated antibody effector functions and T cell responses

…, G Gendron-Lepage, H Medjahed, G Goyette… - Cell host & …, 2021 - cell.com
While the standard regimen of the BNT162b2 mRNA vaccine for SARS-CoV-2 includes two
doses administered 3 weeks apart, some public health authorities are spacing these doses, …

[PDF][PDF] Cross-sectional evaluation of humoral responses against SARS-CoV-2 spike

…, R Duerr, A Laumaea, SP Anand, G Goyette… - Cell Reports …, 2020 - cell.com
SARS-CoV-2 is responsible for the coronavirus disease 2019 (COVID-19) pandemic, infecting
millions of people and causing hundreds of thousands of deaths. The Spike glycoproteins …

[PDF][PDF] Longitudinal analysis of humoral immunity against SARS-CoV-2 Spike in convalescent individuals up to 8 months post-symptom onset

…, H Medjahed, G Gendron-Lepage, G Goyette… - Cell Reports …, 2021 - cell.com
With the recent approval of highly effective coronavirus disease 2019 (COVID-19) vaccines,
functional and lasting immunity to severe acute respiratory syndrome coronavirus 2 (SARS-…

[PDF][PDF] Live imaging of SARS-CoV-2 infection in mice reveals that neutralizing antibodies require Fc function for optimal efficacy

…, R Gasser, C Fink, Y Chen, A Tauzin, G Goyette… - Immunity, 2021 - cell.com
Neutralizing antibodies (NAbs) are effective in treating COVID-19, but the mechanism of
immune protection is not fully understood. Here, we applied live bioluminescence imaging (BLI) …

Decline of humoral responses against SARS-CoV-2 spike in convalescent individuals

…, SP Anand, J Prévost, R Gasser, G Goyette… - MBio, 2020 - Am Soc Microbiol
In the absence of effective vaccines and with limited therapeutic options, convalescent plasma
is being collected across the globe for potential transfusion to coronavirus disease 2019 (…

[PDF][PDF] A Fc-enhanced NTD-binding non-neutralizing antibody delays virus spread and synergizes with a nAb to protect mice from lethal SARS-CoV-2 infection

…, R Gasser, D Chatterjee, D Vézina, G Goyette… - Cell reports, 2022 - cell.com
Emerging evidence indicates that both neutralizing and Fc-mediated effector functions of
antibodies contribute to protection against SARS-CoV-2. It is unclear whether Fc-effector …

[PDF][PDF] Strong humoral immune responses against SARS-CoV-2 Spike after BNT162b2 mRNA vaccination with a 16-week interval between doses

…, G Gendron-Lepage, H Medjahed, G Goyette… - Cell host & …, 2022 - cell.com
The standard regimen of the BNT162b2 mRNA vaccine for SARS-CoV-2 includes two doses
administered three weeks apart. However, some public health authorities spaced these …

[PDF][PDF] Structural basis and mode of action for two broadly neutralizing antibodies against SARS-CoV-2 emerging variants of concern

…, A Tauzin, R Gasser, D Vézina, SP Anand, G Goyette… - Cell reports, 2022 - cell.com
Emerging variants of concern for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
can transmit more efficiently and partially evade protective immune responses, …