Mice lacking the nuclear bile acid receptor FXR/BAR developed normally and were
outwardly identical to wild-type littermates. FXR/BAR null mice were distinguished from wild-type …

PCSK9 proprotein convertase subtilisin/kexin type (PCSK9) is a crucial protein in LDL
cholesterol (LDL-C) metabolism by virtue of its pivotal role in the degradation of the LDL receptor. …

Familial hypercholesterolemia (FH) is one of the most common genetic disorders in humans.
It is an extremely atherogenic metabolic disorder characterized by lifelong elevations of …

The numerous functions of the liver are controlled primarily at the transcriptional level by the
concerted actions of a limited number of hepatocyte-enriched transcription factors (…

Clinical trials have unequivocally shown that inhibition of proprotein convertase subtilisin/kexin
type 9 (PCSK9) efficaciously and safely prevents cardiovascular events by lowering …

Mutations of PCSK9 are associated either with hypercholesterolemia or with hypocholesterolemia.
In the latter case, the incidence of coronary heart disease is reduced, thereby …

This 2022 European Atherosclerosis Society lipoprotein(a) [Lp(a)] consensus statement
updates evidence for the role of Lp(a) in atherosclerotic cardiovascular disease (ASCVD) and …

To elucidate the function of PPARγ in leptin-deficient mouse (ob/ob) liver, a PPARγ liver-null
mouse on an ob/ob background, ob/ob-PPARγ(fl/fl)AlbCre + , was produced using a floxed …

To address the importance of the farnesoid X-receptor (FXR; NR1H4) for normal cholesterol
homeostasis, we evaluated the major pathways of cholesterol metabolism in theFXR-…

High-density lipoproteins (HDL) have many biological functions, including reducing endothelial
activation and adhesion molecule expression. We recently reported that HDL transport …