• The instrument successfully differentiates between highand low-quality guideline content. 7•
The new user’s manual is well received by users. 7• Users provided considerable …

Purpose To update the 2003 American Society of Clinical Oncology technology assessment
on adjuvant use of aromatase inhibitors. Recommendations Based on results from multiple …

Background Smoking is a risk factor for several cancers and may also limit the efficacy of
treatment. In this study, we evaluated the influence of cigarette smoking during radiation …

Anemia resulting from cancer or its treatment is an important clinical problem increasingly
treated with the recombinant hematopoietic growth factor erythropoietin. To address …

… Address reprint requests to George P. Browman, MD, Department of Clinical Epidemiology
and Biostatistics, McMaster University HSC 2C10B, 1200 Main St W, Hamilton, Ontario, …

Objective. —To perform a systematic review of studies evaluating the effectiveness of the
World Health Organization (WHO) analgesic ladder as an intervention for cancer pain …

Background: We undertook research to improve the AGREE instrument, a tool used to evaluate
guidelines. We tested a new seven-point scale, evaluated the usefulness of the original …

Background: We established a program of research to improve the development, reporting
and evaluation of practice guidelines. We assessed the construct validity of the items and user…

Systematic reviews are becoming prominent tools to guide health care decisions. As the
number of published systematic reviews increases, it is common to find more than 1 systematic …

Objective: To evaluate the clinical, methodological, and reporting aspects of systematic
reviews and meta-analyses on the treatment of asthma and to compare those published by the …