Effect of a perioperative, cardiac output–guided hemodynamic therapy algorithm on outcomes following major gastrointestinal surgery: a randomized clinical trial and …
…, N MacDonald, MA Gillies, M Blunt, G Ackland… - Jama, 2014 - jamanetwork.com
Importance Small trials suggest that postoperative outcomes may be improved by the use of
cardiac output monitoring to guide administration of intravenous fluid and inotropic drugs as …
cardiac output monitoring to guide administration of intravenous fluid and inotropic drugs as …
Individualised oxygen delivery targeted haemodynamic therapy in high-risk surgical patients: a multicentre, randomised, double-blind, controlled, mechanistic trial
GL Ackland, S Iqbal, LG Paredes, A Toner… - The Lancet …, 2015 - thelancet.com
Background Morbidity after major surgery is associated with low oxygen delivery. Haemodynamic
therapy aimed at increasing oxygen delivery in an effort to reduce oxygen debt, tissue …
therapy aimed at increasing oxygen delivery in an effort to reduce oxygen debt, tissue …
Association of postoperative high-sensitivity troponin levels with myocardial injury and 30-day mortality among patients undergoing noncardiac surgery
Importance Little is known about the relationship between perioperative high-sensitivity
troponin T (hsTnT) measurements and 30-day mortality and myocardial injury after noncardiac …
troponin T (hsTnT) measurements and 30-day mortality and myocardial injury after noncardiac …
[HTML][HTML] International consensus based review and recommendations for minimum reporting standards in research on transcutaneous vagus nerve stimulation …
…, F Capone, F Panetsos, GL Ackland… - Frontiers in human …, 2021 - frontiersin.org
Given its non-invasive nature, there is increasing interest in the use of transcutaneous
vagus nerve stimulation (tVNS) across basic, translational and clinical research. …
vagus nerve stimulation (tVNS) across basic, translational and clinical research. …
[HTML][HTML] Perioperative quality initiative consensus statement on intraoperative blood pressure, risk and outcomes for elective surgery
…, TE Miller, MPW Grocott, GL Ackland… - British journal of …, 2019 - Elsevier
Background Intraoperative mortality is now rare, but death within 30 days of surgery remains
surprisingly common. Perioperative myocardial infarction is associated with a remarkably …
surprisingly common. Perioperative myocardial infarction is associated with a remarkably …
Functional oxygen sensitivity of astrocytes
…, J Zwicker, AG Teschemacher, GL Ackland… - Journal of …, 2015 - Soc Neuroscience
In terrestrial mammals, the oxygen storage capacity of the CNS is limited, and neuronal
function is rapidly impaired if oxygen supply is interrupted even for a short period of time. …
function is rapidly impaired if oxygen supply is interrupted even for a short period of time. …
Remote ischaemic pre‐and delayed postconditioning–similar degree of cardioprotection but distinct mechanisms
…, J Pernow, PO Sjöquist, GL Ackland… - Experimental …, 2012 - Wiley Online Library
Myocardial ischaemia–reperfusion injury can be significantly reduced by an episode(s) of
ischaemia–reperfusion applied prior to or during myocardial ischaemia (MI) to peripheral …
ischaemia–reperfusion applied prior to or during myocardial ischaemia (MI) to peripheral …
Cardioprotection evoked by remote ischaemic preconditioning is critically dependent on the activity of vagal pre-ganglionic neurones
…, S Kasparov, S Trapp, GL Ackland… - Cardiovascular …, 2012 - academic.oup.com
Aims Innate mechanisms of inter-organ protection underlie the phenomenon of remote
ischaemic preconditioning (RPc) in which episode(s) of ischaemia and reperfusion in tissues …
ischaemic preconditioning (RPc) in which episode(s) of ischaemia and reperfusion in tissues …
Association between complications and death within 30 days after noncardiac surgery
…, CK Chow, CA Polanczyk, W Szczeklik, G Ackland… - Cmaj, 2019 - Can Med Assoc
BACKGROUND: Among adults undergoing contemporary noncardiac surgery, little is
known about the frequency and timing of death and the associations between perioperative …
known about the frequency and timing of death and the associations between perioperative …
[HTML][HTML] A prospective international multicentre cohort study of intraoperative heart rate and systolic blood pressure and myocardial injury after noncardiac surgery …
…, RN Rodseth, PJ Devereaux, GL Ackland - Anesthesia & …, 2018 - journals.lww.com
BACKGROUND: The association between intraoperative cardiovascular changes and
perioperative myocardial injury has chiefly focused on hypotension during noncardiac surgery. …
perioperative myocardial injury has chiefly focused on hypotension during noncardiac surgery. …