Guidelines for medical practice can contribute to improved care only if they succeed in moving
actual practice closer to the behaviors the guidelines recommend. To assess the effect of …

In cohort studies, who does or does not receive an intervention is determined by practice
patterns, personal choice, or policy decisions. This raises the possibility that the intervention …

The broad variation in phenotypes and severities within autism spectrum disorders suggests
the involvement of multiple predisposing factors, interacting in complex ways with normal …

Background Non-fatal outcomes of disease and injury increasingly detract from the ability of
the world's population to live in full health, a trend largely attributable to an epidemiological …

Background Improving survival and extending the longevity of life for all populations requires
timely, robust evidence on local mortality levels and trends. The Global Burden of Disease …

Attack by reactive oxygen intermediates, common to many kinds of cell/tissue injury, has
been implicated in the development of diabetic and other vascular diseases. Such oxygen-free …

We have previously shown that antimicrobial peptides like defensins have the capacity to
mobilize leukocytes in host defense. LL-37 is the cleaved antimicrobial 37-residue, COOH-…

A human bronchial xenograft model was used to characterize the molecular basis for the
previously described defect in bacterial killing that is present in the cystic fibrosis (CF) lung. …

The propensity score—the probability of exposure to a specific treatment conditional on
observed variables—is increasingly being used in observational studies. Creating strata in …

A randomized controlled trial with 76 physicians in 16 community hospitals evaluated audit
and feedback and local opinion leader education as methods of encouraging compliance …